| Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation. | |
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MedLine Citation:
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PMID: 21435587 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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TGF-β1 is a regulatory cytokine that has an important role in controlling T cell differentiation. T cell-produced TGF-β1 acts on T cells to promote Th17 cell differentiation and the development of experimental autoimmune encephalomyelitis (EAE). However, the exact TGF-β1-producing T cell subset required for Th17 cell generation and its cellular mechanism of action remain unknown. Here we showed that deletion of the Tgfb1 gene from activated T cells and Treg cells, but not Treg cells alone, abrogated Th17 cell differentiation, resulting in almost complete protection from EAE. Furthermore, differentiation of T cells both in vitro and in vivo demonstrated that TGF-β1 was highly expressed by Th17 cells and acted in a predominantly autocrine manner to maintain Th17 cells in vivo. These findings reveal an essential role for activated T cell-produced TGF-β1 in promoting the differentiation of Th17 cells and controlling inflammatory diseases. |
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Authors:
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Ilona Gutcher; Moses K Donkor; Qian Ma; Alexander Y Rudensky; Richard A Flavell; Ming O Li |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Immunity Volume: 34 ISSN: 1097-4180 ISO Abbreviation: Immunity Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-25 Completed Date: 2011-05-31 Revised Date: 2013-04-17 |
Medline Journal Info:
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Nlm Unique ID: 9432918 Medline TA: Immunity Country: United States |
Other Details:
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Languages: eng Pagination: 396-408 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autocrine Communication Cell Differentiation* Enzyme-Linked Immunosorbent Assay Flow Cytometry Mice Mice, Inbred C57BL Polymerase Chain Reaction Th17 Cells / cytology*, immunology* Transforming Growth Factor beta1 / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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KO1 AR053595/AR/NIAMS NIH HHS; R01 AR060723/AR/NIAMS NIH HHS; R01 AR060723/AR/NIAMS NIH HHS; R01 AR060723-02/AR/NIAMS NIH HHS; R01 AR060723-03/AR/NIAMS NIH HHS; //Howard Hughes Medical Institute |
| Chemical | |
Reg. No./Substance:
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0/Transforming Growth Factor beta1 |
| Comments/Corrections | |
Comment In:
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Immunity. 2011 Mar 25;34(3):288-90
[PMID:
21435582
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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