Document Detail


Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation.
MedLine Citation:
PMID:  21435587     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
TGF-β1 is a regulatory cytokine that has an important role in controlling T cell differentiation. T cell-produced TGF-β1 acts on T cells to promote Th17 cell differentiation and the development of experimental autoimmune encephalomyelitis (EAE). However, the exact TGF-β1-producing T cell subset required for Th17 cell generation and its cellular mechanism of action remain unknown. Here we showed that deletion of the Tgfb1 gene from activated T cells and Treg cells, but not Treg cells alone, abrogated Th17 cell differentiation, resulting in almost complete protection from EAE. Furthermore, differentiation of T cells both in vitro and in vivo demonstrated that TGF-β1 was highly expressed by Th17 cells and acted in a predominantly autocrine manner to maintain Th17 cells in vivo. These findings reveal an essential role for activated T cell-produced TGF-β1 in promoting the differentiation of Th17 cells and controlling inflammatory diseases.
Authors:
Ilona Gutcher; Moses K Donkor; Qian Ma; Alexander Y Rudensky; Richard A Flavell; Ming O Li
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Immunity     Volume:  34     ISSN:  1097-4180     ISO Abbreviation:  Immunity     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-25     Completed Date:  2011-05-31     Revised Date:  2014-09-11    
Medline Journal Info:
Nlm Unique ID:  9432918     Medline TA:  Immunity     Country:  United States    
Other Details:
Languages:  eng     Pagination:  396-408     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Autocrine Communication
Cell Differentiation*
Enzyme-Linked Immunosorbent Assay
Flow Cytometry
Mice
Mice, Inbred C57BL
Polymerase Chain Reaction
Th17 Cells / cytology*,  immunology*
Transforming Growth Factor beta1 / immunology*
Grant Support
ID/Acronym/Agency:
KO1 AR053595/AR/NIAMS NIH HHS; R01 AR060723/AR/NIAMS NIH HHS; R01 AR060723/AR/NIAMS NIH HHS; //Howard Hughes Medical Institute
Chemical
Reg. No./Substance:
0/Transforming Growth Factor beta1
Comments/Corrections
Comment In:
Immunity. 2011 Mar 25;34(3):288-90   [PMID:  21435582 ]

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