| Autocrine regulation of biliary pathology by activated cholangiocytes. | |
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MedLine Citation:
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PMID: 22194419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The bile duct system of the liver is lined by epithelial cells (i.e., cholangiocytes) that respond to a large number of neuroendocrine factors through alterations in their proliferative activities and the subsequent modification of the microenvironment. As such, activation of biliary proliferation compensates for the loss of cholangiocytes due to apoptosis and slows the progression of toxic injury and cholestasis. Over the course of the last three decades, much progress has been made in identifying the factors that trigger the biliary epithelium to remodel and grow. Because a large number of autocrine factors have recently been identified as relevant clinical targets, a compiled review of their contributions and function in cholestatic liver diseases would be beneficial. In this context, it is important to define the specific processes triggered by autocrine factors that promote cholangiocytes to proliferate, activate neighboring cells, and ultimately lead to extracellular matrix deposition. In this review, we discuss the role of each of the known autocrine factors with particular emphasis on proliferation and fibrogenesis. Because many of these molecules interact with one another throughout the progression of liver fibrosis, a model speculating their involvement in the progression of cholestatic liver disease is also presented. |
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Authors:
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Kendal Jensen; Marco Marzioni; Kamruzzaman Munshi; Syeda Afroze; Gianfranco Alpini; Shannon Glaser |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2011-12-22 |
Journal Detail:
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Title: American journal of physiology. Gastrointestinal and liver physiology Volume: 302 ISSN: 1522-1547 ISO Abbreviation: Am. J. Physiol. Gastrointest. Liver Physiol. Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-02-22 Completed Date: 2012-04-16 Revised Date: 2012-05-23 |
Medline Journal Info:
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Nlm Unique ID: 100901227 Medline TA: Am J Physiol Gastrointest Liver Physiol Country: United States |
Other Details:
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Languages: eng Pagination: G473-83 Citation Subset: IM |
Affiliation:
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Scott & White Digestive Disease Research Center, TX, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autocrine Communication / physiology* Bile Ducts / cytology*, physiology Biliary Tract / pathology* Cell Proliferation / drug effects Endothelins / physiology Epithelial Cells / cytology*, pathology Estrogens / physiology Humans Integrins / physiology Liver Cirrhosis / pathology Neuropeptides / physiology Peptide Hormones / physiology Platelet-Derived Growth Factor / physiology Renin-Angiotensin System / physiology Transforming Growth Factor beta / physiology |
| Grant Support | |
ID/Acronym/Agency:
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DK054811/DK/NIDDK NIH HHS; DK58411/DK/NIDDK NIH HHS; DK76898/DK/NIDDK NIH HHS; R01 DK-081442/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Endothelins; 0/Estrogens; 0/Integrins; 0/Neuropeptides; 0/Peptide Hormones; 0/Platelet-Derived Growth Factor; 0/Transforming Growth Factor beta; 0/platelet-derived growth factor A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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