| Autocrine motility factor receptor signaling pathway promotes cell invasion via activation of ROCK-2 in esophageal squamous cell cancer cells. | |
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MedLine Citation:
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PMID: 20504226 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aberrant overexpression of autocrine motility factor and its receptor (AMFR) is observed in many cancers but not in esophageal squamous cell cancer (ESCC). In this study, upregulated rho-associated protein kinase 2, p-cofilin and intracellular adhesion molecule-1, and downregulated E-cadherin were found in ESCC cells transfected with the plasmid pcDNA 3.1-AMFR-C, while opposite results were observed in ESCC cells transfected with siRNA against AMFR. Additionally, an elevated invasion of ESCC cells by AMFR was reversed by rho-associated protein kinase 2 inhibitor Y-27632, suggesting that AMFR pathway promotes invasion of ESCC cells and may be a potential target for ESCC therapy. |
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Authors:
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Lili Wang; Guiqin Hou; Lexun Xue; Jie Li; Pan Wei; Peirong Xu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-26 |
Journal Detail:
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Title: Cancer investigation Volume: 28 ISSN: 1532-4192 ISO Abbreviation: Cancer Invest. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-16 Completed Date: 2010-12-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8307154 Medline TA: Cancer Invest Country: England |
Other Details:
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Languages: eng Pagination: 993-1003 Citation Subset: IM |
Affiliation:
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Institute of Tumor Molecular Surgery, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blotting, Western Carcinoma, Squamous Cell / metabolism*, pathology Enzyme Activation / physiology Esophageal Neoplasms / metabolism*, pathology Fluorescent Antibody Technique Humans Neoplasm Invasiveness / pathology Receptors, Cytokine / metabolism* Reverse Transcriptase Polymerase Chain Reaction Signal Transduction / physiology* Transfection Ubiquitin-Protein Ligases / metabolism* rho-Associated Kinases / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/ROCK2 protein, human; 0/Receptors, Cytokine; 139568-77-7/autocrine motility factor receptor; EC 2.7.11.1/rho-Associated Kinases; EC 6.3.2.19/Ubiquitin-Protein Ligases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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