Document Detail

Autocrine motility factor receptor signaling pathway promotes cell invasion via activation of ROCK-2 in esophageal squamous cell cancer cells.
MedLine Citation:
PMID:  20504226     Owner:  NLM     Status:  MEDLINE    
Aberrant overexpression of autocrine motility factor and its receptor (AMFR) is observed in many cancers but not in esophageal squamous cell cancer (ESCC). In this study, upregulated rho-associated protein kinase 2, p-cofilin and intracellular adhesion molecule-1, and downregulated E-cadherin were found in ESCC cells transfected with the plasmid pcDNA 3.1-AMFR-C, while opposite results were observed in ESCC cells transfected with siRNA against AMFR. Additionally, an elevated invasion of ESCC cells by AMFR was reversed by rho-associated protein kinase 2 inhibitor Y-27632, suggesting that AMFR pathway promotes invasion of ESCC cells and may be a potential target for ESCC therapy.
Lili Wang; Guiqin Hou; Lexun Xue; Jie Li; Pan Wei; Peirong Xu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-26
Journal Detail:
Title:  Cancer investigation     Volume:  28     ISSN:  1532-4192     ISO Abbreviation:  Cancer Invest.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-16     Completed Date:  2010-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8307154     Medline TA:  Cancer Invest     Country:  England    
Other Details:
Languages:  eng     Pagination:  993-1003     Citation Subset:  IM    
Institute of Tumor Molecular Surgery, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.
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MeSH Terms
Blotting, Western
Carcinoma, Squamous Cell / metabolism*,  pathology
Enzyme Activation / physiology
Esophageal Neoplasms / metabolism*,  pathology
Fluorescent Antibody Technique
Neoplasm Invasiveness / pathology
Receptors, Cytokine / metabolism*
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction / physiology*
Ubiquitin-Protein Ligases / metabolism*
rho-Associated Kinases / metabolism*
Reg. No./Substance:
0/ROCK2 protein, human; 0/Receptors, Cytokine; 139568-77-7/autocrine motility factor receptor; EC Kinases; EC Ligases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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