| Autocrine IL-1β-TRAF6 signalling promotes squamous cell carcinoma invasion through paracrine TNFα signalling to carcinoma-associated fibroblasts. | |
| | |
MedLine Citation:
|
PMID: 22450746 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The invasion of squamous cell carcinoma (SCC) is a significant cause of morbidity and mortality. Here, we identify an E3 ligase, Traf6 and a de-ubiquitinating enzyme, Cezanne/ZA20D1, as important regulators of this process in organotypic models. Traf6 can promote the formation of Cdc42-dependent F-actin microspikes. Furthermore, Traf6 has a key role in autocrine interleukin-1β signalling in SCC cells, which in turn is required to drive the expression of tumour necrosis factor α (TNFα). TNFα acts in a paracrine manner to increase the invasion-promoting potential of carcinoma-associated fibroblasts (CAFs). Exogenous TNFα signalling can restore invasion in cells depleted of Traf6. In conclusion, Traf6 has two important roles in SCC invasion: it promotes cell intrinsic Cdc42-dependent regulation of the actin cytoskeleton and enables production of the paracrine signal, TNFα, that enhances the activity of CAFs. |
| | |
Authors:
|
S I Chaudhry; S Hooper; E Nye; P Williamson; K Harrington; E Sahai |
Related Documents
:
|
20404916 - Mal/srf is dispensable for cell proliferation in drosophila. 17074316 - Tbx1 regulates population, proliferation and cell fate determination of otic epithelial... 9570766 - Ecdysteroids govern two phases of eye development during metamorphosis of the moth, man... 2911386 - A mutation that changes cell movement and cell fate in the zebrafish embryo. 2872166 - A 160-kilodalton epithelial cell surface glycoprotein recognized by plant lectins that ... 10404676 - Further characterization of m cells in gut-associated lymphoid tissues of the chicken. |
Publication Detail:
|
Type: Journal Article Date: 2012-03-26 |
Journal Detail:
|
Title: Oncogene Volume: 32 ISSN: 1476-5594 ISO Abbreviation: Oncogene Publication Date: 2013 Feb |
Date Detail:
|
Created Date: 2013-02-07 Completed Date: 2013-04-12 Revised Date: 2013-04-16 |
Medline Journal Info:
|
Nlm Unique ID: 8711562 Medline TA: Oncogene Country: England |
Other Details:
|
Languages: eng Pagination: 747-58 Citation Subset: IM |
Affiliation:
|
Tumour Cell Biology Laboratory, Cancer Research UK London Research Institute, London, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Autocrine Communication Carcinoma, Squamous Cell / metabolism* Endopeptidases / metabolism* Fibroblasts / metabolism* Humans Interleukin-1beta / metabolism Neoplasm Invasiveness Paracrine Communication Signal Transduction TNF Receptor-Associated Factor 6 / metabolism* Tumor Necrosis Factor-alpha / metabolism cdc42 GTP-Binding Protein / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Interleukin-1beta; 0/TNF Receptor-Associated Factor 6; 0/Tumor Necrosis Factor-alpha; EC 3.4.-/Endopeptidases; EC 3.4.-/OTUD7B protein, human; EC 3.6.5.2/cdc42 GTP-Binding Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder ca...
Next Document: Disrupting the PIKE-A/Akt interaction inhibits glioblastoma cell survival, migration, invasion and c...