| Autobiographical memory in depression: An fMRI study. | |
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MedLine Citation:
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PMID: 22386970 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Depression is associated with three distinct alterations in memory functioning: mood-congruent recall, overgenerality, and intrusive memories. These concern the autobiographical memory system, yet no previous studies have examined the neural correlates of autobiographical memory function in depression. In the present study we used functional magnetic resonance imaging (fMRI) to assess depressed and control participants during an autobiographical memory task. In their first visit to the laboratory, participants wrote a narrative account of a distressing event. Participants were scanned during the second visit while they viewed old items from their narrative and new words or phrases in a recognition memory task. Activity common to both groups during the successful identification of personal emotional memories was observed in regions previously associated with autobiographical memory retrieval. Reduced activity in the depressed group was observed in three regions of the prefrontal cortex associated with cognitive, emotional, and memory inhibition. These results are consistent with a failure by depressed individuals to inhibit task-irrelevant information during an autobiographical memory task. |
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Authors:
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Matthew G Whalley; Michael D Rugg; Chris R Brewin |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-2 |
Journal Detail:
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Title: Psychiatry research Volume: - ISSN: 0165-1781 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7911385 Medline TA: Psychiatry Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Sub-Department of Clinical Health Psychology, University College London, UK; Berkshire Traumatic Stress Service & Clinical Health Psychology Service, 25 Erleigh Road, Reading, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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