Document Detail


Autoantibody to the nuclear antigen RA33: a marker for early rheumatoid arthritis.
MedLine Citation:
PMID:  8448608     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sera from 47 patients with early (< 3 months) arthritis of any type were investigated for anti-RA33, a new anti-nuclear autoantibody characteristic of RA, and the diagnoses determined within the following 8-14 months. In addition, seven patients with unclassified arthritis of > 4 months duration, who were all anti-RA33 positive, were followed for up to 2 years to establish their final rheumatologic diagnoses. Four of 47 early arthritis patients' sera were anti-RA33 positive at the initial evaluation; 14 of these 47 patients (30%) could be classified as RA (according to established criteria) at the final evaluation. All four anti-RA33 positive patients belonged to the RA group (27% of RA patients); of the 33 non-RA patients none had anti-RA33 (P = 0.005). Rheumatoid factor was found in four RA (none of whom had anti-RA33), but also in two non-RA patients (P = 0.05). Finally, the study involved seven additional patients with longer standing, initially unclassified, anti-RA33 positive arthritis: in all of them a diagnosis of RA could be established within 3 years of disease onset. These results suggest that anti-RA33 helps to discriminate early RA from other forms of early arthritis and, in the absence of an established diagnoses, it is predictive of RA. Its discriminative capacity appears to be better than and complementary to that of RF.
Authors:
W Hassfeld; G Steiner; W Graninger; G Witzmann; H Schweitzer; J S Smolen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of rheumatology     Volume:  32     ISSN:  0263-7103     ISO Abbreviation:  Br. J. Rheumatol.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-04-13     Completed Date:  1993-04-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302415     Medline TA:  Br J Rheumatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  199-203     Citation Subset:  AIM; IM    
Affiliation:
2nd Department of Medicine, Lainz Hospital, Vienna, Austria.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Antigens, Nuclear
Arthritis, Rheumatoid / diagnosis*,  immunology*,  radiography
Autoantibodies / analysis*
Biological Markers / analysis
Diagnosis, Differential
Female
Humans
Male
Middle Aged
Nuclear Proteins / immunology*
Rheumatoid Factor / analysis
Chemical
Reg. No./Substance:
0/Antigens, Nuclear; 0/Autoantibodies; 0/Biological Markers; 0/Nuclear Proteins; 9009-79-4/Rheumatoid Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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