Document Detail


Autoantibody titers to oxidized low-density lipoprotein in patients with coronary atherosclerosis.
MedLine Citation:
PMID:  8721636     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oxidation of low-density lipoprotein (LDL) is considered to be the initial step in the atherosclerotic process. Autoantibodies to oxidized LDL (ox-LDL) have been detected in human serum. We used an enzyme-linked immunosorbent assay technique to measure autoantibody titers in 63 normal subjects and patients with coronary artery disease. Thirty-five patients underwent coronary angiography for suspected coronary artery disease. Patients were divided into the following categories: group 1, 20 healthy young volunteers; group 2, 8 patients age-matched to the catheterization patients; group 3, 10 patients with normal coronary angiograms; and group 4, 25 patients with angiographic coronary artery disease. Autoantibody titers to ox-LDL were group 1, 0.142 +/- 0.023; group 2, 0.197 +/- 0.039; group 3, 0.183 +/- 0.038; and group 4, 0.340 +/- 0.026. There was no statistical difference among groups 1, 2, and 3, but the difference between these groups and group 4 was highly significant (p < 0.05). This study demonstrates that (1) autoantibodies to ox-LDL can be detected in normal subjects and in patients with abnormal coronary angiograms and (2) significantly higher titers of autoantibodies to ox-LDL were seen in patients with angiographic evidence of coronary artery disease.
Authors:
M N Bui; M N Sack; G Moutsatsos; D Y Lu; P Katz; R McCown; J A Breall; C E Rackley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  131     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-09-23     Completed Date:  1996-09-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  663-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Internal Medicine, Georgetown University Medical Center, Washington, D.C. 20007, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Autoantibodies / blood*
Coronary Angiography
Coronary Artery Disease / immunology*,  metabolism,  radiography
Enzyme-Linked Immunosorbent Assay
Female
Humans
Lipid Peroxidation
Lipids / immunology
Lipoproteins, LDL / immunology*
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Lipids; 0/Lipoproteins, LDL

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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