Document Detail


Autoantibody profile and clinical correlation in a group of patients with systemic sclerosis in southern Brazil.
MedLine Citation:
PMID:  21779708     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To assess the manifestations of systemic sclerosis (SSc), with an emphasis on the analysis of autoantibodies and their clinical correlations, in a population of patients followed up at the SSc Outpatient Clinics of the Hospital de Clínicas of the Universidade Federal do Paraná.
METHODOLOGY: Cross-sectional study with 96 patients followed up at the SSc Outpatient Clinics of the hospital between September 2007 and September 2009.
RESULTS: Most patients were of the female sex, in their forties or fifties, and the median time of disease was ten years. The limited cutaneous form of SSc was more prevalent. The analysis of the autoantibodies showed the association of anticentromere antibody (ACA) with the following: the limited form of SSc; more advanced age at the time of diagnosis; longer disease time; longer interval between the appearance of the Raynaud's phenomenon (RyP) and the first non-RyP symptom; systemic arterial hypertension (SAH); and cardiac conduction blocks. The antitopoisomerase-1 antibody (ATA-1, previously called anti-Scl-70) was more common in the presence of the diffuse form of SSc, active disease, and digital ulcers. The anti-RNA polymerase III antibody (anti-Pol III) correlated with the diffuse form of SSc, disease activity, and synovitis.
CONCLUSIONS: This study emphasizes and confirms the important role of autoantibodies in assessing patients with SSc, allowing the correlation between the autoimmune profile of patients with SSc and specific manifestations of the disease.
Authors:
Carolina de Souza Müller; Eduardo Dos Santos Paiva; Valderílio Feijó Azevedo; Sebastião Cezar Radominski; José Hermênio Cavalcante Lima Filho
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Revista brasileira de reumatologia     Volume:  51     ISSN:  1809-4570     ISO Abbreviation:  Rev Bras Reumatol     Publication Date:    2011 Jul-Aug
Date Detail:
Created Date:  2011-07-22     Completed Date:  2011-12-08     Revised Date:  2012-05-08    
Medline Journal Info:
Nlm Unique ID:  0404256     Medline TA:  Rev Bras Reumatol     Country:  Brazil    
Other Details:
Languages:  eng; por     Pagination:  314-8, 323-4     Citation Subset:  IM    
Affiliation:
The Systemic Sclerosis Outpatient Clinic of the HC-UFPR. carolinadesmuller@yahoo.com.br
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MeSH Terms
Descriptor/Qualifier:
Autoantibodies / blood*
Brazil
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Scleroderma, Systemic / blood*,  immunology*
Chemical
Reg. No./Substance:
0/Autoantibodies

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