| Autoantibody against, malondialdehyde-modified low density lipoprotein in patients with non-diabetic unstable angina: a potential role in immunologic reaction of plaque instability. | |
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MedLine Citation:
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PMID: 11971214 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of autoantibody against oxidized low-density lipoprotein (LDL) in the pathogenesis of atherosclerosis is still unknown. The purpose of this study was to determine whether autoantibodies against malondialdehyde (MDA)-modified LDL are associated with coronary artery disease (CAD) and clinical presentations of CAD in non-diabetic patients without acute myocardial infarction (AMI). We determined the serum levels of autoantibody against MDA-modified LDL by ELISA in 71 patients with angiographically significant CAD (> or = 50% diameter stenosis in at least 1 vessel) and 80 controls without angiographically significant CAD. Among the total 151 subjects, 30 subjects did not have any clinical ischemic event, 90 subjects had stable angina symptoms, and 31 subjects had unstable angina symptoms. The autoantibody titer, expressed mean optical density units, was significantly higher in patients with CAD than in controls (0.177 +/- 0.014 versus 0.127 +/- 0.011, respectively; p=0.006) and higher in unstable angina group than in stable angina group (0.240 +/- 0.025 versus 0.145 +/- 0.007, respectively; p < 0.001). By logistic regression analysis, the high autoantibody titer was associated significantly with CAD (P=0.008), independent of age, gender, body mass index, triglyceride concentration, and the ratio of total cholesterol-high density lipoprotein (HDL) cholesterol. In multiple regression analysis, presence of CAD, smoking history and low HDL-cholesterol level were independent factors associated with a increased anti-oxLDL Ab titer. The autoantibody titer was significantly lower in nonsmoker than smoker (p=0.019) and higher in low HDL- cholesterol (< or = 35 mg/dl) group than in high HDL-cholesterol group (p=0.012). Elevated autoantibody titer was associated with CAD and the unstable clinical presentation of CAD. Our results suggest that immune response to oxidized LDL may play a role in the pathogenesis of atherosclerosis and plaque instability. |
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Authors:
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Ki Hwan Kwon; Hyuck Moon Kwon; Bum Kee Hong; Dong Soo Kim; Ju Yong Lee; Sung Kee Ryu; Byoung Eun Park; Hyun Young Park; Jeong Ho Kim; Young Won Yoon; Seung Yun Cho; Hyun Seung Kim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Yonsei medical journal Volume: 43 ISSN: 0513-5796 ISO Abbreviation: Yonsei Med. J. Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-04-23 Completed Date: 2002-06-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0414003 Medline TA: Yonsei Med J Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 203-10 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Yonsei University College of Medicine, P.O. Box 1217, Seoul 135-720, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angina, Unstable / blood*, immunology* Antibody Formation Autoantibodies / analysis* Coronary Disease / immunology Female Humans Lipoproteins, LDL / drug effects*, immunology* Male Malondialdehyde / pharmacology* Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Lipoproteins, LDL; 542-78-9/Malondialdehyde |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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