Document Detail


Autoantibody and biopsy grading are associated with expression of ICAM-1, MMP-3, and TRAIL in salivary gland mononuclear cells of Chinese patients with Sjogren's syndrome.
MedLine Citation:
PMID:  19332626     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Sjögren's syndrome (SS) is an inflammatory autoimmune disease. We investigated important factors associated with the expression of inflammation-related molecules in minor salivary gland (MSG) mononuclear cells in patients with SS. METHODS: Thirty-four patients with SS with a MSG biopsy grading of either grade III (10 patients) or grade IV (24 patients) were enrolled. The age, sex, autoantibodies, cell infiltration, and intercellular adhesion molecule-1 (ICAM-1), matrix metalloproteinase-3 (MMP-3), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), or CXCR3 expression were also analyzed. RESULTS: Ten of the 34 patients with SS were diagnosed with secondary SS; in these patients, the diagnosis of rheumatoid arthritis was confirmed in 8 and systemic lupus erythematosus in 2. TRAIL and ICAM-1 were overexpressed in patients with antinuclear antibodies (ANA) > 1:160, compared to those with titer < 1:160 (45.1 +/- 4.4 vs 41.2 +/- 3.9, p = 0.021, and 15.2 +/- 5.7 vs 10.8 +/- 3.3, p = 0.018, respectively). Higher erythrocyte sedimentation rate (ESR; >OR= 20) was associated with higher TRAIL expression and CD20 cell infiltration in contrast to lower ESR (< 20; p < 0.05). ICAM-1, TRAIL, and MMP-3 were expressed more predominantly in anti-SSA-positive than in anti-SSA-negative patients with SS. There was a significant difference in CD20 cell infiltration and MMP-3 expression between primary SS and secondary SS. Biopsy of a grade IV showed a significantly increased expression of TRAIL (44.9 +/- 4.5 vs 40.8 +/- 3.6, p = 0.013) and MMP-3 (62.7 +/- 6.3 vs 54.4 +/- 7.3, p = 0.003) in mononuclear cells as compared to those of grade III. CONCLUSION: In our study, pathologic grading with a higher grade (grade IV) and the presence of SSA or a higher titer of ANA were significantly associated with the overexpression of TRAIL, MMP-3, or ICAM-1 in the salivary gland mononuclear cells in patients with SS.
Authors:
Wei-Sheng Chen; Kuan-Chia Lin; Chun-Hsiung Chen; Hsien-Tzung Liao; Hon-Pin Wang; Wing-Yin Li; Hui-Ting Lee; Chang-Youh Tsai; Chung-Tei Chou
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Publication Detail:
Type:  Journal Article     Date:  2009-03-30
Journal Detail:
Title:  The Journal of rheumatology     Volume:  36     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-13     Completed Date:  2009-06-19     Revised Date:  2009-07-09    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  989-96     Citation Subset:  IM    
Affiliation:
Department of Medicine, Division of Allergy, Immunology and Rheumatology, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Beitou District, Taipei, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Antibodies, Antinuclear / blood*
Asian Continental Ancestry Group
Biological Markers / metabolism
Epithelial Cells / metabolism*,  pathology
Female
Fluorescent Antibody Technique, Indirect
Humans
Immunoenzyme Techniques
Intercellular Adhesion Molecule-1 / metabolism*
Male
Matrix Metalloproteinase 3 / metabolism*
Middle Aged
Salivary Glands, Minor / immunology,  metabolism*,  pathology
Sjogren's Syndrome / immunology,  metabolism*,  pathology
TNF-Related Apoptosis-Inducing Ligand / metabolism*
Taiwan
Young Adult
Chemical
Reg. No./Substance:
0/Antibodies, Antinuclear; 0/Biological Markers; 0/TNF-Related Apoptosis-Inducing Ligand; 0/TNFSF10 protein, human; 126547-89-5/Intercellular Adhesion Molecule-1; EC 3.4.24.17/Matrix Metalloproteinase 3
Comments/Corrections
Erratum In:
J Rheumatol. 2009 Jun;36(6):1351

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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