| Autoantibody against survivin in patients with systemic sclerosis. | |
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MedLine Citation:
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PMID: 20551096 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: In patients with systemic sclerosis (SSc), to determine concentrations of antibodies against survivin and their clinical association with SSc, and to evaluate serum survivin concentrations. METHODS: Anti-survivin antibody was examined by ELISA and immunoblotting using human recombinant survivin. Serum survivin levels were assessed by ELISA. RESULTS: IgG but not IgM anti-survivin antibody levels in patients with SSc were significantly higher than those in healthy controls and patients with systemic lupus erythematosus (SLE). When cutoff values were set as mean + 2 SD of control, IgG anti-survivin antibodies were positive in 41% (25/61) of patients with SSc, while they were detected in only 1 healthy individual (3%, 1/29) and 1 patient with SLE (5%, 1/20). Regarding the clinical correlation, patients with SSc who were positive for IgG anti-survivin antibody exhibited significantly longer disease duration than those who were negative. Immunoblotting analysis confirmed the presence of anti-survivin antibody in sera from patients with SSc. Serum survivin levels in patients with SSc were also significantly higher than in controls and patients with SLE. CONCLUSION: Our results suggest that autoantibody against survivin is generated in patients with SSc, especially those with long disease duration. |
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Authors:
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Yuta Koike; Eiji Muroi; Ayumi Yoshizaki; Fumihide Ogawa; Koichi Yanaba; Motoi Takenaka; Kazuhiro Shimizu; Shinichi Sato |
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Publication Detail:
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Type: Journal Article Date: 2010-06-15 |
Journal Detail:
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Title: The Journal of rheumatology Volume: 37 ISSN: 0315-162X ISO Abbreviation: J. Rheumatol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: Canada |
Other Details:
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Languages: eng Pagination: 1864-70 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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