Document Detail

Autoantibodies to tumor necrosis factor in patients with rheumatoid arthritis and systemic lupus erythematosus.
MedLine Citation:
PMID:  19273453     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To detect autoantibodies to tumor necrosis factor (TNF) in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), and to determine their clinical correlates. METHODS: Ninety-two patients with RA and 62 with SLE were studied. Sera were examined for autoantibodies to TNF by enzyme linked immunoassay. Levels of these autoantibodies were analyzed in respect to markers of inflammation such as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and joint erosions, as well as other clinical, laboratory, and therapeutic aspects of RA and SLE. RESULTS: Anti-TNF levels were higher in those RA patients without erosions, but did not correlate with ESR or CRP. CONCLUSION: These observations suggest that autoantibody anti-TNF may be part of the innate immune system and may contribute to decreased inflammation in patients with RA.
Barbara J Rosenau; Peter H Schur
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Publication Detail:
Type:  Journal Article     Date:  2009-02-27
Journal Detail:
Title:  The Journal of rheumatology     Volume:  36     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-03     Completed Date:  2009-06-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  753-6     Citation Subset:  IM    
Department of Medicine, Brigham and Women's Hospital, 75 Francis St., Boston, MA 02115, USA.
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MeSH Terms
Arthritis, Rheumatoid* / blood,  immunology
Autoantibodies / blood*
Lupus Erythematosus, Systemic* / blood,  immunology
Middle Aged
Tumor Necrosis Factor-alpha / immunology*
Reg. No./Substance:
0/Autoantibodies; 0/Tumor Necrosis Factor-alpha

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