| Autoantibodies to sympathetic ganglia, GAD, or tyrosine phosphatase in long-term IDDM with and without ECG-based cardiac autonomic neuropathy. | |
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MedLine Citation:
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PMID: 9167116 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the association of autoantibodies to complement-fixing sympathetic ganglia (CF-SG), and tyrosine phosphatase (IA-2) with electrocardiogram (ECG)-based cardiac autonomic neuropathy (CAN) in long-term IDDM. RESEARCH DESIGN AND METHODS: We examined the prevalence of autoantibodies to CF-SG (by complement-fixing indirect immunoflourescence), GAD, and IA-2 (by radioligand assay) and islet cells (by indirect immunofluorescence) in 96 long-term IDDM patients (41 with ECG-based CAN, > or = 2 of 5 cardiac reflex tests abnormal; 55 without ECG-based CAN). As a control group, 89 healthy nondiabetic subjects were investigated. RESULTS: CF-SG autoantibodies were observed more frequently in long-term IDDM patients than in the control group (25 vs. 4%, P = 0.0001). Of the IDDM patients, 14 (34%) with CAN and 10 (18%) without CAN presented with CF-SG autoantibodies (P = 0.06). GAD or IA-2 autoantibodies were detected in 14 (34%) and 17 (41%) IDDM patients with CAN, compared with 24 (44%) and 29 (53%) IDDM patients without CAN (P = 0.2, P = 0.2). Islet cell antibodies were observed in 6 (15%) IDDM patients with and in 9 (16%) IDDM patients without CAN (P = 0.5). CONCLUSIONS: In long-term IDDM, the role of CF-SG autoantibodies, which tend to be more frequent in patients with ECG-based CAN, requires further investigations. The persistence of GAD and IA-2 autoantibodies is not related to ECG-based CAN. |
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Authors:
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D Muhr; U Mollenhauer; A G Ziegler; M Haslbeck; E Standl; O Schnell |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Diabetes care Volume: 20 ISSN: 0149-5992 ISO Abbreviation: Diabetes Care Publication Date: 1997 Jun |
Date Detail:
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Created Date: 1997-07-24 Completed Date: 1997-07-24 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7805975 Medline TA: Diabetes Care Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1009-12 Citation Subset: IM |
Affiliation:
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Diabetes Research Institute, Schwabing City Hospital, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Autoantibodies / blood* Autoantigens Diabetes Mellitus, Type 1 / blood, immunology*, physiopathology* Diabetic Neuropathies / blood, immunology*, physiopathology Electrocardiography* Female Fluorescent Antibody Technique, Indirect Ganglia, Sympathetic / immunology* Glutamate Decarboxylase / immunology Heart / innervation* Heart Rate Humans Male Membrane Proteins / immunology Protein Tyrosine Phosphatase, Non-Receptor Type 1 Protein Tyrosine Phosphatases / immunology Receptor-Like Protein Tyrosine Phosphatases, Class 8 Reference Values Valsalva Maneuver |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Autoantigens; 0/Membrane Proteins; EC 3.1.3.48/PTPRN protein, human; EC 3.1.3.48/Protein Tyrosine Phosphatase, Non-Receptor Type 1; EC 3.1.3.48/Protein Tyrosine Phosphatases; EC 3.1.3.48/Receptor-Like Protein Tyrosine Phosphatases, Class 8; EC 4.1.1.15/Glutamate Decarboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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