Document Detail


Autoantibodies to sympathetic ganglia, GAD, or tyrosine phosphatase in long-term IDDM with and without ECG-based cardiac autonomic neuropathy.
MedLine Citation:
PMID:  9167116     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the association of autoantibodies to complement-fixing sympathetic ganglia (CF-SG), and tyrosine phosphatase (IA-2) with electrocardiogram (ECG)-based cardiac autonomic neuropathy (CAN) in long-term IDDM. RESEARCH DESIGN AND METHODS: We examined the prevalence of autoantibodies to CF-SG (by complement-fixing indirect immunoflourescence), GAD, and IA-2 (by radioligand assay) and islet cells (by indirect immunofluorescence) in 96 long-term IDDM patients (41 with ECG-based CAN, > or = 2 of 5 cardiac reflex tests abnormal; 55 without ECG-based CAN). As a control group, 89 healthy nondiabetic subjects were investigated. RESULTS: CF-SG autoantibodies were observed more frequently in long-term IDDM patients than in the control group (25 vs. 4%, P = 0.0001). Of the IDDM patients, 14 (34%) with CAN and 10 (18%) without CAN presented with CF-SG autoantibodies (P = 0.06). GAD or IA-2 autoantibodies were detected in 14 (34%) and 17 (41%) IDDM patients with CAN, compared with 24 (44%) and 29 (53%) IDDM patients without CAN (P = 0.2, P = 0.2). Islet cell antibodies were observed in 6 (15%) IDDM patients with and in 9 (16%) IDDM patients without CAN (P = 0.5). CONCLUSIONS: In long-term IDDM, the role of CF-SG autoantibodies, which tend to be more frequent in patients with ECG-based CAN, requires further investigations. The persistence of GAD and IA-2 autoantibodies is not related to ECG-based CAN.
Authors:
D Muhr; U Mollenhauer; A G Ziegler; M Haslbeck; E Standl; O Schnell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetes care     Volume:  20     ISSN:  0149-5992     ISO Abbreviation:  Diabetes Care     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-07-24     Completed Date:  1997-07-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7805975     Medline TA:  Diabetes Care     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1009-12     Citation Subset:  IM    
Affiliation:
Diabetes Research Institute, Schwabing City Hospital, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Autoantibodies / blood*
Autoantigens
Diabetes Mellitus, Type 1 / blood,  immunology*,  physiopathology*
Diabetic Neuropathies / blood,  immunology*,  physiopathology
Electrocardiography*
Female
Fluorescent Antibody Technique, Indirect
Ganglia, Sympathetic / immunology*
Glutamate Decarboxylase / immunology
Heart / innervation*
Heart Rate
Humans
Male
Membrane Proteins / immunology
Protein Tyrosine Phosphatase, Non-Receptor Type 1
Protein Tyrosine Phosphatases / immunology
Receptor-Like Protein Tyrosine Phosphatases, Class 8
Reference Values
Valsalva Maneuver
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Autoantigens; 0/Membrane Proteins; EC 3.1.3.48/PTPRN protein, human; EC 3.1.3.48/Protein Tyrosine Phosphatase, Non-Receptor Type 1; EC 3.1.3.48/Protein Tyrosine Phosphatases; EC 3.1.3.48/Receptor-Like Protein Tyrosine Phosphatases, Class 8; EC 4.1.1.15/Glutamate Decarboxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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