Document Detail

Autoantibodies to serotonin in serum of patients with psychiatric disorders.
MedLine Citation:
PMID:  14572623     Owner:  NLM     Status:  MEDLINE    
Antibodies to serotonin in serum were investigated by ELISA in patients with paranoid schizophrenia (N=27), schizoaffective psychosis (N=38), depression (N=67), Alzheimer's disease (N=21), chronic alcoholism (N=43), rheumatoid arthritis (N=25), and multiple sclerosis (N=16), and in healthy volunteers (N=60). Increased antibody reactivity to serotonin was found in schizoaffective psychosis, chronic alcoholism, and rheumatoid arthritis. Decreased antibody reactivity to serotonin was found in multiple sclerosis and depression. These anti-serotonin antibodies belong to the class of so-called natural autoantibodies. Alterations of these natural autoantibodies could indicate a disturbance to the immune system. It is possible that these antibodies could also influence receptor function. Autoantibodies to neurotransmitters in a wide spectrum of psychiatric disorders have not previously been reported.
Klaus Schott; Jacques-Emmanuel Schaefer; Elke Richartz; Anil Batra; Beate Eusterschulte; Reinhild Klein; Peter Alfred Berg; Mathias Bartels; Karl Mann; Gerhard Buchkremer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychiatry research     Volume:  121     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-10-23     Completed Date:  2004-04-21     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  51-7     Citation Subset:  IM    
Department of Psychiatry and Psychotherapy, University of Tübingen, Osianderstr. 24, D-72076, Tübingen, Federal Republic of Germany.
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MeSH Terms
Aged, 80 and over
Alcoholism / immunology
Alzheimer Disease / immunology
Arthritis, Rheumatoid / immunology
Autoantibodies / blood*
Depressive Disorder / immunology
Enzyme-Linked Immunosorbent Assay
Mental Disorders / immunology*
Middle Aged
Multiple Sclerosis / immunology
Psychotic Disorders / immunology
Reference Values
Schizophrenia, Paranoid / immunology
Serotonin / immunology*
Reg. No./Substance:
0/Autoantibodies; 50-67-9/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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