Document Detail


Autoantibodies to recombinant lipocortin-1 in rheumatoid arthritis and systemic lupus erythematosus.
MedLine Citation:
PMID:  2554826     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Corticosteroids may mediate some of their anti-inflammatory effects via induction of a specific 38 kD protein, lipocortin-1. Autoantibodies to lipocortin-1 were measured by enzyme linked immunosorbent assay (ELISA) in 90 healthy subjects and in 63 patients with rheumatoid arthritis (RA), 36 with systemic lupus erythematosus (SLE), 26 with polymyalgia rheumatica, and 13 with chronic airways disease. Sixteen patients with RA receiving prolonged, high steroid doses (prednisolone greater than 7.5 mg/day) had raised IgM antilipocortin-1 levels, while 19 patients with RA untreated with steroids had normal levels. This association was independent of disease activity. In SLE, raised antilipocortin-1 levels were associated with active disease and were independent of steroid treatment. Antilipocortin-1 antibody levels were not raised in patients with polymyalgia rheumatica and chronic airways disease. Thus steroid treatment alone appears insufficient to induce antilipocortin-1 antibodies, unless an underlying autoimmune state is also present. In RA, antilipocortin-1 antibodies may impair anti-inflammatory actions of steroids and render some patients 'steroid resistant'.
Authors:
N J Goulding; M R Podgorski; N D Hall; R J Flower; J L Browning; R B Pepinsky; P J Maddison
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  48     ISSN:  0003-4967     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-12-15     Completed Date:  1989-12-15     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  843-50     Citation Subset:  IM    
Affiliation:
Bath Institute for Rheumatic Diseases, University of Bath, UK.
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MeSH Terms
Descriptor/Qualifier:
Aged
Annexins
Arthritis, Rheumatoid / immunology*
Autoantibodies / analysis*
Calcium-Binding Proteins / immunology*
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulin M / analysis*
Lung Diseases, Obstructive / immunology
Lupus Erythematosus, Systemic / immunology*
Male
Middle Aged
Phosphoric Monoester Hydrolases / immunology
Polymyalgia Rheumatica / immunology
Prednisolone / therapeutic use
Recombinant Proteins / immunology
Chemical
Reg. No./Substance:
0/Annexins; 0/Autoantibodies; 0/Calcium-Binding Proteins; 0/Immunoglobulin M; 0/Recombinant Proteins; 50-24-8/Prednisolone; EC 3.1.3.-/Phosphoric Monoester Hydrolases
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