Document Detail


Autoantibodies to oxidized low density lipoprotein in relation with coronary artery disease.
MedLine Citation:
PMID:  19729805     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The relationship between autoantibodies (autoAbs) to oxidized LDL (oxLDL) and coronary artery disease (CAD) remains controversial. IgM and IgG autoAbs to oxLDL and 1-palmitoyl-2 (5'-oxo-valeroyl)-sn-glycero-3-phosphorylcholine (POVPC), as well as the levels of non modified or modified ApoB-100 immune complexes (ICs), were measured in twenty patients undergoing clinically indicated coronary angiography, and in ten young healthy volunteer sera. The levels of IgM autoAbs to oxLDL did not differ between no CAD patients and healthy subjects, but the levels of these autoAbs were significantly higher in no CAD patients and healthy subjects in comparison with CAD patients. There was not difference in the levels of IgM anti-ApoB-100 ICs between both groups of patients. In contrast, the levels of ICs formed by IgM autoAbs and oxidative modified ApoB-100 were lower in patients with CAD than in patients without CAD. No differences were observed in the levels of autoAbs to POVPC among the groups. In conclusion, our results showed that the level of circulating oxLDL IgM autoAbs was lower in CAD patients than in no CAD patients, supporting the hypothesis that this kind of autoAbs might be inversely associated with the presence of atherosclerosis.
Authors:
Yosdel Soto; Héctor Conde; Ronald Aroche; Víctor Brito; Patricia Luaces; Alfredo Nasiff; Angel Obregón; Ana María Vázquez López
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human antibodies     Volume:  18     ISSN:  1875-869X     ISO Abbreviation:  Hum Antibodies     Publication Date:  2009  
Date Detail:
Created Date:  2009-09-04     Completed Date:  2009-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9711270     Medline TA:  Hum Antibodies     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  109-17     Citation Subset:  IM    
Affiliation:
Center of Molecular Immunology, Havana, Cuba.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Apolipoprotein B-100 / immunology
Autoantibodies / analysis,  immunology*
Cholesterol / blood
Coronary Angiography
Coronary Artery Disease / immunology*
Enzyme-Linked Immunosorbent Assay
Humans
Immunoglobulin G / biosynthesis
Immunoglobulin M / biosynthesis
Lipoproteins, LDL / immunology*
Middle Aged
Phospholipid Ethers / immunology
Phospholipids / immunology
Receptors, Oxidized LDL / immunology
Triglycerides / blood
Chemical
Reg. No./Substance:
0/1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine; 0/Apolipoprotein B-100; 0/Autoantibodies; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Lipoproteins, LDL; 0/Phospholipid Ethers; 0/Phospholipids; 0/Receptors, Oxidized LDL; 0/Triglycerides; 0/oxidized low density lipoprotein; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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