Document Detail

Autoantibodies to glutamic acid decarboxylase in downbeat nystagmus.
MedLine Citation:
PMID:  12810806     Owner:  NLM     Status:  MEDLINE    
The cause of downbeat nystagmus (DBN) remains undiagnosed in about 40% of patients. This paper reports the presence of antiglutamic acid decarboxylase antibodies (GAD-Ab) in a patient with DBN. Antibodies against GABAergic neurons located in the vestibular complex may induce chemical denervation of the floccular neurons, which normally suppress the peripheral imbalance between vertical semicircular canal systems, thereby causing DBN. Testing for GAD-Ab may be indicated in DBN patients without an identifiable anatomical brain lesion.
G Antonini; R Nemni; F Giubilei; F Gragnani; V Ceschin; S Morino; E Bucci; N Accornero
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  74     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-06-17     Completed Date:  2003-07-22     Revised Date:  2008-11-20    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  998-9     Citation Subset:  IM    
Department of Neurological Sciences, University of Rome, La Sapienza, Rome, Italy.
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MeSH Terms
Autoantibodies / analysis,  immunology*
Glutamate Decarboxylase / immunology*
Nystagmus, Pathologic / immunology*,  pathology
Receptors, GABA-A / physiology
Reg. No./Substance:
0/Autoantibodies; 0/Receptors, GABA-A; EC Decarboxylase

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