| Autoantibodies to glutamic acid decarboxylase in downbeat nystagmus. | |
| | |
MedLine Citation:
|
PMID: 12810806 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The cause of downbeat nystagmus (DBN) remains undiagnosed in about 40% of patients. This paper reports the presence of antiglutamic acid decarboxylase antibodies (GAD-Ab) in a patient with DBN. Antibodies against GABAergic neurons located in the vestibular complex may induce chemical denervation of the floccular neurons, which normally suppress the peripheral imbalance between vertical semicircular canal systems, thereby causing DBN. Testing for GAD-Ab may be indicated in DBN patients without an identifiable anatomical brain lesion. |
| | |
Authors:
|
G Antonini; R Nemni; F Giubilei; F Gragnani; V Ceschin; S Morino; E Bucci; N Accornero |
Related Documents
:
|
6118886 - Comparative effects of aspartate and glutamate during myocardial ischemia. 8104636 - Immunocytochemistry of amino-acids in the rodent pituitary using extremely specific, ve... 579136 - Antagonizing effect of aspartic acid on the development of physical dependence on and t... 2872146 - Production of methionine and glutamic acid from n-alkanes by serratia marcescens var. k... 6769106 - Preparation of l- and d-[1-14c]lysine by the resolution of dl-[1-14 c]lysine. 1417916 - D-xylose fermentation and catabolism in fusarium oxysporum. |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Journal of neurology, neurosurgery, and psychiatry Volume: 74 ISSN: 0022-3050 ISO Abbreviation: J. Neurol. Neurosurg. Psychiatr. Publication Date: 2003 Jul |
Date Detail:
|
Created Date: 2003-06-17 Completed Date: 2003-07-22 Revised Date: 2008-11-20 |
Medline Journal Info:
|
Nlm Unique ID: 2985191R Medline TA: J Neurol Neurosurg Psychiatry Country: England |
Other Details:
|
Languages: eng Pagination: 998-9 Citation Subset: IM |
Affiliation:
|
Department of Neurological Sciences, University of Rome, La Sapienza, Rome, Italy. antoninimusc@uniroma1.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Autoantibodies / analysis, immunology* Female Glutamate Decarboxylase / immunology* Humans Nystagmus, Pathologic / immunology*, pathology Receptors, GABA-A / physiology |
| Chemical | |
Reg. No./Substance:
|
0/Autoantibodies; 0/Receptors, GABA-A; EC 4.1.1.15/Glutamate Decarboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prolonged survival in motor neuron disease: a descriptive study of the King's database 1990-2002.
Next Document: Detection of Staphylococcus aureus by 16S rRNA directed in situ hybridisation in a patient with a br...