| Autoantibodies and Sjögren's syndrome: a physiologist's perspective. | |
| | |
MedLine Citation:
|
PMID: 22208652 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Sjögren's syndrome is a systemic autoimmune condition centred around salivary gland dysfunction and atrophy. There are a plethora of antibodies that mark the decline of the salivary glands, most of which relate to apoptopic mediated destruction of acinar cells. The best known of these autoantibodies, anti-Ro and anti-La form part of the diagnostic criteria for the condition. An emerging viewpoint in recent years is that glandular dysfunction precedes rather than follows glandular atrophy and attention has shifted to the interface between the immune system and the secretory process. An autoantibody against the muscarinic type 3 acetylcholine receptor occupies precisely this position because it inhibits the acetylcholine receptor which controls salivary and lacrimal fluid secretion. The consequence of identifying an autoantibody that can cause rather than simply reflect the disease process are manifold and could have a huge impact on development of therapeutic treatments. Furthermore, a "functional" autoantibody directed against an important component of the autonomic nervous system could also account for some of the extraglandular features of Sjögren's syndrome. |
| | |
Authors:
|
Peter M Smith; Luke J Dawson |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-2 |
Journal Detail:
|
Title: Current pharmaceutical biotechnology Volume: - ISSN: 1873-4316 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-2 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100960530 Medline TA: Curr Pharm Biotechnol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
School of Dental Sciences, University of Liverpool, Liverpool L69 3BX. petesmif@liv.ac.uk. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ectopic lymphoid neogenesis and lymphoid chemokines in Sjogren's syndrome: at the interplay between ...
Next Document: B-Lymphocytes govern the Pathogenesis of Sjögren's Syndrome.