Document Detail

Autoantibodies and primary Sjögren's syndrome in a hypocitraturic stone population.
MedLine Citation:
PMID:  9060088     Owner:  NLM     Status:  MEDLINE    
Primary Sjögren's syndrome may be complicated by distal renal tubular acidosis (dRTA) and hypocitraturia, which are risk factors for calcium stone formation. Approached from a different perspective, in patients with urolithiasis and dRTA, autoantibodies and various autoimmune diseases are not uncommon. In search for signs of autoimmune disease, we analysed antinuclear antibodies and total levels of serum IgG in 197 hypocitraturic stone formers (67 women and 130 men). Antinuclear antibodies were present in 1.5% of the men and in 18% of the women. An isolated increase in serum IgG was found in 9% of the men and in 3% of the women. Anti-SS-A antibodies were analysed in a subgroup of 46 women and were estimated to occur in 16% of all hypocitraturic stone forming women. Four of 4 examined women, but no men, fulfilled the criteria of definite or possible primary Sjögren's syndrome. We recommend the analysis of anti-SS-A antibodies in female hypocitraturic stone formers.
P Eriksson; T Denneberg; I Lundström; T Skogh; H G Tiselius
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of urology and nephrology     Volume:  31     ISSN:  0036-5599     ISO Abbreviation:  Scand. J. Urol. Nephrol.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-05-30     Completed Date:  1997-05-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0114501     Medline TA:  Scand J Urol Nephrol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  73-80     Citation Subset:  IM    
Department of Internal Medicine, Hospital of Jönköping, Sweden.
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MeSH Terms
Aged, 80 and over
Antibodies, Antinuclear / blood
Autoantibodies / blood*
Autoimmune Diseases / diagnosis*,  immunology
Citric Acid / urine*
Glomerular Filtration Rate / physiology
Immunoglobulin G / blood
Kidney Calculi / diagnosis*,  immunology
Kidney Tubular Necrosis, Acute / diagnosis*,  immunology
Middle Aged
Sex Factors
Sjogren's Syndrome / diagnosis*,  immunology
Reg. No./Substance:
0/Antibodies, Antinuclear; 0/Autoantibodies; 0/Immunoglobulin G; 0/SS-A antibodies; 0/SS-B antibodies; 77-92-9/Citric Acid

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