Document Detail

Autoantibodies in silicosis patients and in silica-exposed individuals.
MedLine Citation:
PMID:  19705119     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to evaluate the prevalence of autoantibodies in silica-exposed patients with and without silicosis and without any known rheumatic disease. We studied 61 males exposed to silica for a mean time of 12.2 +/- 10.2 years of exposure. A total of 72.1% (44/61) of them presented with pulmonary silicosis. As control group we included 62 healthy males. In all samples we screened for rheumatoid factor (latex agglutination), antinuclear antibodies (indirect immunofluorescence), anti Scl-70 (ELISA) and ANCA (indirect immunofluorescence technique). One patient (1.6%) of the silica group had weakly positive ANA (titer 1:80, centromeric pattern); one (1.6%) had atypical ANCA and seven patients (11.4%) presented positive rheumatoid factor (values range from 8 to 32 UI/ml). One control patient had a positive RF and none of them had positive ANA or ANCA. All patients and controls were negative for anti-Scl-70. The finding of positive RF was higher in the silica-exposed patients (p = 0.032; Fisher). All patients with positive RF had pulmonary silicosis. In the silica-exposed group we could not find a relationship between the presence of RF and age (p = 0.21; Mann-Whitney), smoking habits (p = 0.25; Fisher) but a positive relationship was found with exposure time to silica dust (p = 0.005; Mann-Whitney). We conclude that there was 11.4% prevalence of low titer RF in the silica-exposed patients without known rheumatic disease. RF was more common in patients with longer exposure to silica dust and appeared only in those with silicosis. The presence of ANA, Scl-70 and ANCA was the same as in the control population.
Gabriel Zaghi; Fábio Koga; Renato M Nisihara; Thelma L Skare; Antonieta Handar; Shirley R Rosa Utiyama; Marilia Barreto Silva
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-25
Journal Detail:
Title:  Rheumatology international     Volume:  30     ISSN:  1437-160X     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-27     Completed Date:  2011-01-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1071-5     Citation Subset:  IM    
Rheumatology Unit, Curitiba's Evangelic University Hospital, Rua João Alencar Guimarães, 796, Curitiba, PR, 80310420, Brazil.
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MeSH Terms
Antibodies, Antineutrophil Cytoplasmic / biosynthesis,  blood
Antibodies, Antinuclear / biosynthesis,  blood
Autoantibodies / biosynthesis,  blood*
Environmental Exposure / adverse effects
Hep G2 Cells
Middle Aged
Rheumatic Diseases / blood,  epidemiology*,  immunology*
Rheumatoid Factor / biosynthesis,  blood
Silicon Dioxide / immunology*,  poisoning
Silicosis / blood,  epidemiology*,  immunology*
Reg. No./Substance:
0/Antibodies, Antineutrophil Cytoplasmic; 0/Antibodies, Antinuclear; 0/Autoantibodies; 7631-86-9/Silicon Dioxide; 9009-79-4/Rheumatoid Factor

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