| Autoantibodies in normal and abnormal pregnancy. | |
| | |
MedLine Citation:
|
PMID: 1285899 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Abnormal autoimmune function has been associated with reproductive failure for decades. In fact, all medical conditions historically associated with pregnancy loss (and on occasion infertility) are now recognized to have an autoimmune etiology. It is therefore quite surprising that only less than a decade ago a correlation between the presence of abnormal autoantibodies and pregnancy loss was reported for the first time. Since reproductive failure, similar to other abnormal autoimmune states, is not a monoclonal event, we have established that affected patients demonstrate polyclonal autoantibody abnormalities including a variety of nonorganospecific as well as organspecific autoantibody groupings. For example, patients with repeated pregnancy loss will exhibit abnormal levels of anti-phospholipid antibodies (PA). In normal pregnancy natural autoantibodies do not follow the standard immunoglobulin (Ig) pattern, characterized by a decrease in levels despite a probably mild increase in production, which is excessively compensated by the vasodilatation of pregnancy. PA, especially, demonstrate a mild increase during pregnancy, though levels only in the peripartal period may reach abnormally high titers (in comparison to nonpregnant controls). This dichotomy between total Ig and natural autoantibodies is interesting since it suggests that autoantibodies may be under distinct control. In fact, we have suggested that this observed elevation of autoantibodies may be the result of an antigenic stimulus by self-like antigen, represented by the maternal growth of the parasitic fetus. In abnormal pregnancies, especially those associated with maternal hypertension and fetal growth retardation (IUGR), autoantibody levels do reach highly abnormal levels.(ABSTRACT TRUNCATED AT 250 WORDS) |
| | |
Authors:
|
N Gleicher |
Related Documents
:
|
2649759 - Autoimmune disease in pregnancy. 1336919 - Lupus anticoagulant and anticardiolipin antibodies in an obstetric population. 1285869 - Condition specific antepartum testing: systemic lupus erythematosus and associated sero... 1923159 - Anticardiolipin antibodies in patients with recurrent pregnancy wastage: treatment and ... 16389029 - Reduction of circulating annexin a5 levels and resistance to annexin a5 anticoagulant a... 12139139 - Congenital heart block in neonatal lupus: the pediatric cardiologist's perspective. 2431889 - Development of lumbar spinal cord and cortical evoked potentials after tibial nerve sti... 1294039 - Surgical treatment of obstructive azoospermia. 1127569 - Diapause in ornithomya biloba dufour (diptera: hippoboscidae) parasitic on fairy martin... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 28 ISSN: 1046-7408 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 1992 Oct-Dec |
Date Detail:
|
Created Date: 1993-03-18 Completed Date: 1993-03-18 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: DENMARK |
Other Details:
|
Languages: eng Pagination: 269-73 Citation Subset: IM |
Affiliation:
|
Center for Human Reproduction, Chicago, IL 60610. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abortion, Habitual
/
etiology,
immunology Antibodies, Antiphospholipid / analysis Antiphospholipid Syndrome / immunology, physiopathology Autoantibodies / analysis* Autoantigens / immunology, metabolism Autoimmune Diseases / complications, immunology* Autoimmunity* Female Fetal Growth Retardation / etiology, immunology Fetus / immunology* Humans Maternal-Fetal Exchange Pre-Eclampsia / immunology Pregnancy / immunology* Pregnancy Complications / immunology* |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Antiphospholipid; 0/Autoantibodies; 0/Autoantigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Neonatal lupus erythematosus in offspring of mothers with experimental systemic lupus erythematosus.
Next Document: Immune reproductive failure: effect of nonspecific immunostimulation in mouse model.