Document Detail


Autoantibodies in neurodegenerative diseases: antigen-specific frequencies and intrathecal analysis.
MedLine Citation:
PMID:  9661995     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The frequency of autoantibodies (AAbs) was surveyed in several neurodegenerative diseases, other neurological diseases, and controls using antigen-specific EIAs for neurofilament heavy subunit, tubulin, glial fibrillary acidic protein, S100 protein, tau, beta-amyloid peptide, myelin basic protein, and heparan sulfate proteoglycan. High frequencies of sera and cerebrospinal fluid tubulin AAbs were found in Alzheimer disease (62% and 69%, respectively), Parkinson disease (27% and 70%), amyotrophic lateral sclerosis (54% and 67%), and in sera from multiple sclerosis (50% and 67%), optic neuritis (85%), Guillain-Barré syndrome (88%), and vascular dementia (52%). High frequencies of neurofilament heavy subunit AAbs were detected in Guillain-Barré syndrome, chronic peripheral neuropathy (88%) and optic neuritis (62%); whereas, some Alzheimer's disease (33%) and vascular dementia (44%) patients had glial fibrillary acidic protein AAbs. Lower frequencies of other AAbs were found in patient groups. AAb results were also compared to functional assessment of blood-brain barrier integrity in Parkinson's disease and Alzheimer's disease. The relevance of these AAbs to pathogenesis and/or course of neurologic diseases merits further study with particular reference to subgrouping and prognosis.
Authors:
J W Terryberry; G Thor; J B Peter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurobiology of aging     Volume:  19     ISSN:  0197-4580     ISO Abbreviation:  Neurobiol. Aging     Publication Date:    1998 May-Jun
Date Detail:
Created Date:  1998-09-16     Completed Date:  1998-09-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8100437     Medline TA:  Neurobiol Aging     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  205-16     Citation Subset:  IM    
Affiliation:
Specialty Laboratories, Santa Monica, CA 90404, USA. jterryberry@specialtylabs.com
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MeSH Terms
Descriptor/Qualifier:
Antibody Specificity
Antigens / analysis*
Autoantibodies / analysis*
Hippocampus / immunology
Humans
Immunoblotting
Immunoenzyme Techniques
Nerve Tissue Proteins / immunology
Neurodegenerative Diseases / immunology*
Chemical
Reg. No./Substance:
0/Antigens; 0/Autoantibodies; 0/Nerve Tissue Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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