Document Detail


Autoantibodies bind solubilized calcium channel-omega-conotoxin complexes from small cell lung carcinoma: a diagnostic aid for Lambert-Eaton myasthenic syndrome.
MedLine Citation:
PMID:  2557495     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serum autoantibodies found by radioimmunoassay in 27 of 52 patients with the Lambert-Eaton myasthenic syndrome (LES) bound specifically to a soluble omega-conotoxin binding component of a voltage-gated Ca2+ channel (VGCC) complex extracted from small cell lung carcinoma (SCC). These antibodies were not found in 43 control patients with other neurologic diseases, including myasthenia gravis, peripheral neuropathies, and amyotrophic lateral sclerosis, or in 9 patients with endocrine autoimmunity, but they were found in 2 of 21 control patients with SCC without a history of LES, 1 of whom had severe autonomic neuropathy. Seropositivity was more frequent in patients with LES who had evidence of a primary lung cancer (76%) than in those with other neoplasms or without evidence of cancer (30%). Antigens extracted from SCC tumor lines derived from patients with and without LES and from a human neuroblastoma line yielded results that were highly correlated. A control extract of colonic carcinoma (derived from a patient with LES) yielded negative results. The data implicate a tumor-associated VGCC as the autoimmunizing stimulus in a subset of patients with LES and provide the first direct evidence that the VGCC complex in SCC is a target for some LES antibodies. The serologic test described should be a useful aid in diagnosing LES.
Authors:
V A Lennon; E H Lambert
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Mayo Clinic proceedings     Volume:  64     ISSN:  0025-6196     ISO Abbreviation:  Mayo Clin. Proc.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-02-05     Completed Date:  1990-02-05     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0405543     Medline TA:  Mayo Clin Proc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1498-504     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoantibodies / metabolism*
Binding Sites, Antibody / immunology,  physiology
Calcium Channels / metabolism*
Carcinoma, Small Cell / immunology*
Conotoxins*
Evaluation Studies as Topic
Humans
Iodine Radioisotopes / diagnostic use*
Ion Channel Gating
Lambert-Eaton Myasthenic Syndrome / immunology*
Lung Neoplasms / immunology*
Mice
Mollusk Venoms / diagnostic use*
Precipitin Tests / methods
Radioimmunoassay
Solubility
Tumor Cells, Cultured / immunology
Grant Support
ID/Acronym/Agency:
CA 37343/CA/NCI NIH HHS; NS 23691/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Calcium Channels; 0/Conotoxins; 0/Iodine Radioisotopes; 0/Mollusk Venoms; 93438-65-4/conotoxin GV

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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