Document Detail


Autoantibodies, autoimmune disease, and the birth of immune diagnostics.
MedLine Citation:
PMID:  23154275     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The appearance of autoantibody to DNA followed sequentially by the disappearance of anti-DNA and appearance of DNA antigen in a patient with systemic lupus erythematosus demonstrated that autoantibodies participate in immune complex-mediated pathogenesis. Continuing studies showed that autoantibodies are also useful biomarkers in clinical diagnosis and important reagents for elucidating the structure and function of intracellular proteins in cell biology. Recently, autoantibodies to tumor-associated antigens have been identified in cancer, and these findings have expanded the field of cancer immunodiagnostics.
Authors:
Eng M Tan
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-11-01
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  122     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-16     Completed Date:  2013-01-15     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3835-6     Citation Subset:  AIM; IM    
Affiliation:
The Scripps Research Institute, La Jolla, California 92037, USA. emtan@scripps.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Antinuclear / immunology*
Antigen-Antibody Complex / immunology
Antigens, Neoplasm / immunology*
Humans
Immunologic Tests / methods*
Lupus Erythematosus, Systemic / diagnosis*,  immunology
Neoplasms / diagnosis*,  immunology
Chemical
Reg. No./Substance:
0/Antibodies, Antinuclear; 0/Antigen-Antibody Complex; 0/Antigens, Neoplasm
Comments/Corrections

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