Document Detail

Autoantibodies against oxidized LDL are associated with severe chest pain attacks in patients with coronary heart disease.
MedLine Citation:
PMID:  16298691     Owner:  NLM     Status:  MEDLINE    
Autoantibodies against oxidized low-density lipoprotein (oxLDL) predict the progression of atherosclerosis. Several studies have shown that oxLDL is present in atherosclerotic lesions and that several factors present in active atherosclerotic plaques can oxidatively modify LDL. Oxidation of LDL induces production of autoantibodies against oxLDL (oxLDLab) that can be measured using an EIA test. Our aim was to see whether oxLDLab are associated with severe chest pain attacks in coronary heart disease (CHD) patients. Patients having two- or three-vessel CHD, as assessed by coronary angiography, and their siblings were recruited into the study (n = 568, mean age 55.8 years, range 29.3-83.2 years). Nondiabetic patients having a history of severe chest pain attacks had significantly higher oxLDLab levels (0.611 +/- 0.56) than those who did not have a history of severe chest pain attacks (0.487 +/- 0.40) (p = 0.027), even though age, cholesterol level, body mass index, and blood pressure were similar in both groups. However, no difference was found in oxLDLab levels in diabetic patients with or without a history of severe chest pain attacks. Increased levels of oxLDL autoantibodies are associated with severe chest pain attacks in nondiabetic patients with CHD.
Jukka S Luoma; Anu Kareinen; Outi Närvänen; Laura Viitanen; Markku Laakso; Seppo Ylä-Herttuala
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2005-09-01
Journal Detail:
Title:  Free radical biology & medicine     Volume:  39     ISSN:  0891-5849     ISO Abbreviation:  Free Radic. Biol. Med.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-21     Completed Date:  2006-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8709159     Medline TA:  Free Radic Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1660-5     Citation Subset:  IM    
A.I. Virtanen Institute of Molecular Sciences, University of Kuopio, P.O. Box 1627, FIN-70211 Kuopio, Finland.
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MeSH Terms
Aged, 80 and over
Autoantibodies / blood*
Chest Pain / blood*,  etiology
Coronary Disease / blood*,  complications,  diagnosis*
Diabetes Mellitus / blood*
Immunoenzyme Techniques / methods
Lipoproteins, LDL / immunology*
Middle Aged
Predictive Value of Tests
Sensitivity and Specificity
Reg. No./Substance:
0/Autoantibodies; 0/Lipoproteins, LDL; 0/oxidized low density lipoprotein

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