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Autoantibodies against galectins are associated with antiphospholipid syndrome in patients with systemic lupus erythematosus.
MedLine Citation:
PMID:  22887862     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The presence of autoantibodies against immunoregulatory effectors can be relevant for onset and/or progression of autoimmune disease. Emerging insights into immunological activity profile including a role as opsonins give reason to systematically monitor sera of patients for immunoglobulin G autoantibodies, preferably for several galectins at the same time. Here we report on a study of chronic inflammatory rheumatic diseases, i.e. systemic lupus erythematosus (SLE; pilot cohort p: n=40; confirmation cohort c: n=109), rheumatoid arthritis (RA; p: n=32; c: n=25) and primary antiphospholipid syndrome (APS; c: n=64). ELISA-based series using galectins-1, -2, -3, -4, -7, -8, and -9 and natural processing products, i.e. the truncated version of galectin-3 and the N-terminal domains of galectins-4, -8, and -9, were performed. Healthy donors (NHD; p: n=20; c: n=21) and patients with paraproteins (PP; c: n=19) served as controls. Highly significant OD-value readings for IgG autoantibodies were consistently detected for the proto-type galectin-7 (SLE) and the tandem-repeat-type galectins-8 and -9 (SLE and RA). Their presence was independent from the autoantibody status against double-stranded DNA (for patients with SLE) or rheumatoid factor (for patients with RA), respectively. Importantly, anti-galectin-2 autoantibodies highly significantly correlated with the appearance of a secondary antiphospholipid syndrome in patients with SLE so that this parameter may serve as an additional biomarker for APS. Equally of note, the presence of IgG autoantibodies against galectins capable to act as opsonin may contribute to a sustained immune dysregulation in patients with chronic inflammatory rheumatic diseases.
Authors:
Kerstin Sarter; Christina Janko; Sabine André; Luis E Muñoz; Christine Schorn; Silke Winkler; Jürgen Rech; Herbert Kaltner; Hanns-Martin Lorenz; Martin Schiller; Laura Andreoli; Angelo A Manfredi; David A Isenberg; Georg Schett; Martin Herrmann; Hans-Joachim Gabius
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-11
Journal Detail:
Title:  Glycobiology     Volume:  -     ISSN:  1460-2423     ISO Abbreviation:  Glycobiology     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9104124     Medline TA:  Glycobiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nuremberg, 91054 Erlangen, Germany.
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