| Autoantibodies against cardiolipin in the serum of patients with colorectal adenocarcinoma: their prognostic significance. | |
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MedLine Citation:
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PMID: 9493695 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using an ELISA method, the sera of 43 patients with colon adenocarcinoma (CA) and of 26 surgical patients with nonmalignant disease of the gastrointestinal tract were studied for the presence of autoantibodies against cardiolipin (CLP) before and 1 month after surgery. Forty healthy volunteers were used as controls. Fourteen CA patients were found to be positive for anti-CLP autoantibodies before surgical treatment, and 15 patients were found to be positive 1 month after surgery. The difference between the group of CA patients and either the group of patients with nonmalignant diseases of the GI tract, or the group of healthy individuals was statistically significant (p = 0.003). The group of CA patients with high anti-CLP serum titer had a better outcome compared with the group of patients without detectable autoantibody titer (p = 0.08), estimated based on the frequency of recurrences, during the follow-up period. Further studies are in progress to evaluate the significance of anti-CLP antibodies as a biological marker of prognosis in CA patients. |
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Authors:
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K N Syrigos; A Charalampopoulos; M M Konstantoulakis; A Karayiannakis; V Tsibloulis; P Peveretos |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes Volume: 30 ISSN: 0014-312X ISO Abbreviation: Eur Surg Res Publication Date: 1998 |
Date Detail:
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Created Date: 1998-03-26 Completed Date: 1998-03-26 Revised Date: 2006-11-30 |
Medline Journal Info:
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Nlm Unique ID: 0174752 Medline TA: Eur Surg Res Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 55-60 Citation Subset: IM |
Affiliation:
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First Department of Propaedeutic Surgery, Athens Medical School, Hippokration Hospital, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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immunology* Adult Aged Antibodies, Anticardiolipin / blood* Colorectal Neoplasms / immunology* Female Humans Male Middle Aged Prognosis |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Anticardiolipin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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