Document Detail


Autoantibodies against cardiolipin in the serum of patients with colorectal adenocarcinoma: their prognostic significance.
MedLine Citation:
PMID:  9493695     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using an ELISA method, the sera of 43 patients with colon adenocarcinoma (CA) and of 26 surgical patients with nonmalignant disease of the gastrointestinal tract were studied for the presence of autoantibodies against cardiolipin (CLP) before and 1 month after surgery. Forty healthy volunteers were used as controls. Fourteen CA patients were found to be positive for anti-CLP autoantibodies before surgical treatment, and 15 patients were found to be positive 1 month after surgery. The difference between the group of CA patients and either the group of patients with nonmalignant diseases of the GI tract, or the group of healthy individuals was statistically significant (p = 0.003). The group of CA patients with high anti-CLP serum titer had a better outcome compared with the group of patients without detectable autoantibody titer (p = 0.08), estimated based on the frequency of recurrences, during the follow-up period. Further studies are in progress to evaluate the significance of anti-CLP antibodies as a biological marker of prognosis in CA patients.
Authors:
K N Syrigos; A Charalampopoulos; M M Konstantoulakis; A Karayiannakis; V Tsibloulis; P Peveretos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes     Volume:  30     ISSN:  0014-312X     ISO Abbreviation:  Eur Surg Res     Publication Date:  1998  
Date Detail:
Created Date:  1998-03-26     Completed Date:  1998-03-26     Revised Date:  2006-11-30    
Medline Journal Info:
Nlm Unique ID:  0174752     Medline TA:  Eur Surg Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  55-60     Citation Subset:  IM    
Affiliation:
First Department of Propaedeutic Surgery, Athens Medical School, Hippokration Hospital, Greece.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / immunology*
Adult
Aged
Antibodies, Anticardiolipin / blood*
Colorectal Neoplasms / immunology*
Female
Humans
Male
Middle Aged
Prognosis
Chemical
Reg. No./Substance:
0/Antibodies, Anticardiolipin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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