Document Detail

Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I.
MedLine Citation:
PMID:  20123958     Owner:  NLM     Status:  MEDLINE    
Most patients with autoimmune polyendocrine syndrome type I (APS-I) display chronic mucocutaneous candidiasis (CMC). We hypothesized that this CMC might result from autoimmunity to interleukin (IL)-17 cytokines. We found high titers of autoantibodies (auto-Abs) against IL-17A, IL-17F, and/or IL-22 in the sera of all 33 patients tested, as detected by multiplex particle-based flow cytometry. The auto-Abs against IL-17A, IL-17F, and IL-22 were specific in the five patients tested, as shown by Western blotting. The auto-Abs against IL-17A were neutralizing in the only patient tested, as shown by bioassays of IL-17A activity. None of the 37 healthy controls and none of the 103 patients with other autoimmune disorders tested had such auto-Abs. None of the patients with APS-I had auto-Abs against cytokines previously shown to cause other well-defined clinical syndromes in other patients (IL-6, interferon [IFN]-gamma, or granulocyte/macrophage colony-stimulating factor) or against other cytokines (IL-1beta, IL-10, IL-12, IL-18, IL-21, IL-23, IL-26, IFN-beta, tumor necrosis factor [alpha], or transforming growth factor beta). These findings suggest that auto-Abs against IL-17A, IL-17F, and IL-22 may cause CMC in patients with APS-I.
Anne Puel; Rainer Döffinger; Angels Natividad; Maya Chrabieh; Gabriela Barcenas-Morales; Capucine Picard; Aurélie Cobat; Marie Ouachée-Chardin; Antoine Toulon; Jacinta Bustamante; Saleh Al-Muhsen; Mohammed Al-Owain; Peter D Arkwright; Colm Costigan; Vivienne McConnell; Andrew J Cant; Mario Abinun; Michel Polak; Pierre-François Bougnères; Dinakantha Kumararatne; László Marodi; Amit Nahum; Chaim Roifman; Stéphane Blanche; Alain Fischer; Christine Bodemer; Laurent Abel; Desa Lilic; Jean-Laurent Casanova
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-02-01
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  207     ISSN:  1540-9538     ISO Abbreviation:  J. Exp. Med.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-16     Completed Date:  2010-09-20     Revised Date:  2013-03-11    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  291-7     Citation Subset:  IM    
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM), U550, 75015 Paris, France.
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MeSH Terms
Autoantibodies / blood,  immunology
Blotting, Western
Candidiasis, Chronic Mucocutaneous / blood,  etiology,  immunology*
Child, Preschool
Flow Cytometry
Interferon-gamma / immunology
Interleukin-17 / immunology*
Interleukins / immunology*
Middle Aged
Polyendocrinopathies, Autoimmune / blood,  complications,  immunology*
Young Adult
Grant Support
5UL1RR024143-03/RR/NCRR NIH HHS; //Howard Hughes Medical Institute
Reg. No./Substance:
0/Autoantibodies; 0/Interleukin-17; 0/Interleukins; 0/interleukin-22; 82115-62-6/Interferon-gamma
Comment In:
J Exp Med. 2010 Feb 15;207(2):264-5   [PMID:  20123956 ]

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