Document Detail

AutoPap system performance in screening for low prevalence and small cell abnormalities.
MedLine Citation:
PMID:  9022727     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To summarize the design principles of the AutoPap System evaluation score by evaluating slides having a low prevalence of abnormal cells and small cell abnormalities and assessing the evaluation score as a diagnostic tool. STUDY DESIGN: Data from two clinical studies conducted using the AutoPap System and data obtained from the evaluation score training slides were analyzed to demonstrate the effectiveness of the evaluation score. The clinical studies included a prospective, intended-use study involving approximately 13,000 slides and a comprehensive sensitivity study using approximately 1,200 slides from five laboratories. The evaluation score training set consisted of 4,174 slides from 10 laboratories. RESULTS: The robust design of the AutoPap evaluation score was demonstrated by similar detection capabilities and sensitivities to slides having either a low or high prevalence of abnormal cells. No significant difference in performance was detected between the small cell slides and the comparison groups of carcinoma in situ and invasive squamous carcinoma having normal-sized abnormal cells. In addition, the evaluation scores corresponded well to the diagnostic severity of the slides.
J S Lee; P Wilhelm; L Kuan; D G Ellison; X Lei; S Oh; S F Patten
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta cytologica     Volume:  41     ISSN:  0001-5547     ISO Abbreviation:  Acta Cytol.     Publication Date:    1997 Jan-Feb
Date Detail:
Created Date:  1997-03-06     Completed Date:  1997-03-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370307     Medline TA:  Acta Cytol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  56-64     Citation Subset:  IM    
NeoPath, Inc., Redmond, Washington 98052, USA.
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MeSH Terms
Carcinoma, Squamous Cell / diagnosis,  pathology
Cell Size
Cervical Intraepithelial Neoplasia / diagnosis,  pathology
Cervix Uteri / pathology*
Clinical Trials as Topic
Evaluation Studies as Topic
Image Interpretation, Computer-Assisted / instrumentation*
Mass Screening / instrumentation*
Multicenter Studies as Topic
Prospective Studies
Quality Control
Sensitivity and Specificity
Severity of Illness Index
Uterine Cervical Neoplasms / diagnosis,  pathology
Vaginal Smears / instrumentation*
Comment In:
Acta Cytol. 1997 Nov-Dec;41(6):1853-4   [PMID:  9390156 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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