Document Detail


Auto-stimulatory action of secreted caveolin-1 on the proliferation of Ewing's sarcoma cells.
MedLine Citation:
PMID:  21373757     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Caveolin-1 (CAV1) is highly expressed in Ewing's sarcoma (EWS). We previously showed that increased cellular CAV1 is associated with the regulation of the tumorigenicity, drug resistance and metastatic ability of EWS cells. Because several studies reported that melanoma and prostate cancer cells, which express relatively high CAV1 levels, secrete CAV1, and that secreted CAV1 is associated with tumor progression, our study explored the possibility that EWS cells also secreted CAV1 and that secreted CAV1 may contribute to EWS pathobiology. Results from experiments involving the ectopic expression of a Myc-tagged CAV1 protein in EWS cells as well as the supplementation of culture media with purified CAV1 protein followed by its intracellular localization using immunofluorescence demonstrated that EWS cells secrete CAV1, that they are able to take up the secreted protein, and that extracellular CAV1 enhances EWS cell proliferation. These findings strongly support the notion that secreted CAV1 may also contribute to the malignant properties of EWS.
Authors:
Aniruddha Sengupta; Silvia Mateo-Lozano; Oscar M Tirado; Vicente Notario
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-03-03
Journal Detail:
Title:  International journal of oncology     Volume:  38     ISSN:  1791-2423     ISO Abbreviation:  Int. J. Oncol.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-03-22     Completed Date:  2011-08-03     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  9306042     Medline TA:  Int J Oncol     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  1259-65     Citation Subset:  IM    
Affiliation:
Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.
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MeSH Terms
Descriptor/Qualifier:
Bone Neoplasms / metabolism,  pathology*
Caveolin 1 / secretion*
Cell Line, Tumor
Cell Proliferation / drug effects
Humans
Sarcoma, Ewing / metabolism,  pathology*,  secretion
Grant Support
ID/Acronym/Agency:
P30-CA-CA51008/CA/NCI NIH HHS; R01 CA134727-01/CA/NCI NIH HHS; R01 CA134727-02/CA/NCI NIH HHS; R01 CA134727-03/CA/NCI NIH HHS; R01 CA134727-04/CA/NCI NIH HHS; R01-CA134727/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Caveolin 1
Comments/Corrections

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