| Auto-immune cholangiopathy in a juvenile patient with systemic lupus erythematosus. | |
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MedLine Citation:
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PMID: 22277082 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Systemic lupus erythematosus (SLE) is a multi-system inflammatory disease characterised by the presence of auto-antibodies. Liver enzyme abnormalities are common but clinical liver dysfunction with jaundice is rare. We report a juvenile female patient with SLE who developed jaundice nine months after her initial presentation. Further investigations including liver biopsy and magnetic resonance cholangio-pancreatography (MRCP) revealed two likely pathologies for her liver dysfunction; amoxicillin-clavulanic acid induced cholestasis and auto-immune cholangiopathy. The hyperbilirubinaemia resolved spontaneously three months after exposure to amoxicillin-clavulanic acid, however the elevation in Alanine transaminase (ALT) and Gamma-glutamyl transpeptidase (GGT) persisted until intensive immunosuppressive therapy achieved complete remission. Conclusion: We report a rare case of a juvenile patient with SLE and auto-immune cholangiopathy. The use of cholangio-pancreatography as part of the diagnostic work-up achieved the final diagnosis. © 2012 The Author(s)/Acta PÃdiatrica © 2012 Foundation Acta PÃdiatrica. |
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Authors:
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Gabriele Noble-Jamieson; David Jayne; C Elizabeth Hook |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-25 |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: - ISSN: 1651-2227 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Author(s)/Acta PÃdiatrica © 2012 Foundation Acta PÃdiatrica. |
Affiliation:
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From the Departments of Paediatric Gastroenterology, Hepatology & Nutrition, Adult Renal Medicine and Histopathology at Addenbrookes NHS Trust, Cambridge University Hospitals, Hills Road, Cambridge CB2 0QQ. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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