Document Detail

Auto-crosslinked hyaluronan gel injections in phonosurgery.
MedLine Citation:
PMID:  20304276     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate the clinical performance of an auto-crosslinked gel obtained from hyaluronic acid (ACP-based gel) as an anti-adhesive agent and/or augmentative agent in vocal cord surgery for the treatment of vocal fold (VF) atrophy, sulcus vocalis, and postsurgery scarring as well as its tolerability at short- and long-term follow-up. STUDY DESIGN: This was a prospective multicenter trial conducted between 2007 and 2009. SETTING: Academic center. SUBJECTS AND METHODS: Inclusion criteria were patients with glottic gap due to previous endoscopic phonosurgery, VF scars, vocal cord atrophy, and sulcus vocalis. Forty patients who underwent endoscopic injection of hyaluronic acid under general anesthesia were enrolled. Two different injections sites were used: the thyroarytenoid muscle in cases of glottic gap for augmentative purposes, and the lamina propria for treatment of scars and sulcus vocalis. A voice-evaluation protocol was performed before surgery, at the first follow-up visit (3 mo), and at the final follow-up (12 mo). RESULTS: Follow-up data at three months were available for 38 patients, while data at 12 months follow-up were available for 27 patients. No side effects, hematoma, or infection and allergic reactions were reported in either the perioperative or postoperative period. Patients had statistically significant improvement in voice parameters compared with the baseline data at the first follow-up visit and at the 12-month follow-up. CONCLUSION: ACP-based gel seems to be a new tool in the challenging treatment of VF scarring, functioning as both an anti-adhesive product and an augmentation agent. Improvements in all glottal parameters and in both objective and subjective evaluation of voice performance were observed.
Gabriele Molteni; Giuseppe Bergamini; Andrea Ricci-Maccarini; Caterina Marchese; Angelo Ghidini; Matteo Alicandri-Ciufelli; Maria Pia Luppi; Livio Presutti
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery     Volume:  142     ISSN:  1097-6817     ISO Abbreviation:  Otolaryngol Head Neck Surg     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-22     Completed Date:  2010-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8508176     Medline TA:  Otolaryngol Head Neck Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  547-53     Citation Subset:  IM    
Copyright Information:
Copyright 2010 American Academy of Otolaryngology-Head and Neck Surgery Foundation. Published by Mosby, Inc. All rights reserved.
Department of Otolaryngology-Head and Neck Surgery, University of Modena and Reggio Emilia, Policlinico di Modena, Modena, Italy.
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MeSH Terms
Hyaluronic Acid / administration & dosage*
Middle Aged
Otorhinolaryngologic Surgical Procedures / methods
Prospective Studies
Treatment Outcome
Vocal Cords / pathology,  surgery*
Voice Disorders / surgery
Voice Quality
Reg. No./Substance:
0/Gels; 9004-61-9/Hyaluronic Acid

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