| Autistic behavior, FMR1 protein, and developmental trajectories in young males with fragile X syndrome. | |
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MedLine Citation:
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PMID: 11450815 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the context of a longitudinal study, we assessed the relationship between ratings of autistic behavior, FMR1 protein expression (FMRP), and the developmental trajectories of 55 young males with fragile X syndrome. Autistic behavior, as measured by the Childhood Autism Rating Scale, was not related to FMRP expression. However, autistic behavior was a significant predictor of both developmental status and developmental change. Boys with both autistic behavior and fragile X syndrome functioned at significantly lower levels of development and grew at significantly slower rates than those without autistic behavior. FMRP expression accounted for less variance in developmental level than did autistic behavior, and was not significantly related to slope (developmental change over time). No autistic behavior x FMRP interaction was found. |
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Authors:
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D B Bailey; D D Hatton; M Skinner; G Mesibov |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of autism and developmental disorders Volume: 31 ISSN: 0162-3257 ISO Abbreviation: J Autism Dev Disord Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-07-13 Completed Date: 2001-12-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7904301 Medline TA: J Autism Dev Disord Country: United States |
Other Details:
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Languages: eng Pagination: 165-74 Citation Subset: IM |
Affiliation:
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Frank Porter Graham Child Development Center, University of North Carolina at Chapel Hill, 27599, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Autistic Disorder
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complications,
metabolism* Child Child Development* Child, Preschool Fragile X Mental Retardation Protein Fragile X Syndrome / complications, metabolism*, psychology* Gene Expression Humans Linear Models Longitudinal Studies Male Nerve Tissue Proteins / analysis* Psychiatric Status Rating Scales RNA-Binding Proteins* |
| Chemical | |
Reg. No./Substance:
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0/FMR1 protein, human; 0/Nerve Tissue Proteins; 0/RNA-Binding Proteins; 139135-51-6/Fragile X Mental Retardation Protein |
| Comments/Corrections | |
Comment In:
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J Autism Dev Disord. 2002 Feb;32(1):60-1
[PMID:
11916334
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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