Document Detail

Autism spectrum disorder and Klinefelter syndrome.
MedLine Citation:
PMID:  17401614     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Autism is a severe handicapping disorder of early childhood characterized by a distinct pattern of social and communication impairment with rigid ritualistic interests. In about 10-25% of cases, it is associated with known medical conditions. Population-based studies of autism have found that Klinefelter's syndrome (KS), a common chromosome abnormality, is sometimes associated with autism. However, few detailed case descriptions of patients with KS and autism have not been published. CASE REPORT: In this paper, we describe the occurrence of autistic features in two cases of Klinefelter syndrome, one with the typical XXY karyotype and the other with the XXYY variant. CONCLUSION: Autistic features may be more common in persons with Klinefelter syndrome than generally believed. We propose that all patients with KS should be screened for the presence of autism.
P Jha; D Sheth; M Ghaziuddin
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-03-30
Journal Detail:
Title:  European child & adolescent psychiatry     Volume:  16     ISSN:  1018-8827     ISO Abbreviation:  Eur Child Adolesc Psychiatry     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-22     Completed Date:  2007-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9212296     Medline TA:  Eur Child Adolesc Psychiatry     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  305-8     Citation Subset:  IM    
Division of Child Psychiatry, University of Michigan Hospital, 200 East Hospital Drive, Ann Arbor, MI 48109-0277, USA.
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MeSH Terms
Attention Deficit Disorder with Hyperactivity / complications,  diagnosis
Autistic Disorder / complications,  diagnosis*,  genetics
Communication Disorders / complications
Depression / complications,  diagnosis
Diagnosis, Differential
Klinefelter Syndrome / complications,  diagnosis*,  genetics
Mass Screening
Social Alienation
Social Behavior

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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