| Autism spectrum disorder and Klinefelter syndrome. | |
MedLine Citation:
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PMID: 17401614 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Autism is a severe handicapping disorder of early childhood characterized by a distinct pattern of social and communication impairment with rigid ritualistic interests. In about 10-25% of cases, it is associated with known medical conditions. Population-based studies of autism have found that Klinefelter's syndrome (KS), a common chromosome abnormality, is sometimes associated with autism. However, few detailed case descriptions of patients with KS and autism have not been published. CASE REPORT: In this paper, we describe the occurrence of autistic features in two cases of Klinefelter syndrome, one with the typical XXY karyotype and the other with the XXYY variant. CONCLUSION: Autistic features may be more common in persons with Klinefelter syndrome than generally believed. We propose that all patients with KS should be screened for the presence of autism. |
Authors:
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P Jha; D Sheth; M Ghaziuddin |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2007-03-30 |
Journal Detail:
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Title: European child & adolescent psychiatry Volume: 16 ISSN: 1018-8827 ISO Abbreviation: Eur Child Adolesc Psychiatry Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-08-22 Completed Date: 2007-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9212296 Medline TA: Eur Child Adolesc Psychiatry Country: Germany |
Other Details:
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Languages: eng Pagination: 305-8 Citation Subset: IM |
Affiliation:
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Division of Child Psychiatry, University of Michigan Hospital, 200 East Hospital Drive, Ann Arbor, MI 48109-0277, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Attention Deficit Disorder with Hyperactivity / complications, diagnosis Autistic Disorder / complications, diagnosis*, genetics Child Communication Disorders / complications Comorbidity Depression / complications, diagnosis Diagnosis, Differential Genotype Humans Karyotyping Klinefelter Syndrome / complications, diagnosis*, genetics Male Mass Screening Social Alienation Social Behavior |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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