| Autism: the point of view from fragile X studies. | |
| | |
MedLine Citation:
|
PMID: 9813775 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The relationship between the fragile X syndrome (FXS) and autism is reviewed. Shortly after the FXS was first described, it was noted that certain behaviors commonly found in afflicted individuals resemble certain features of autism. Research concerning a possible relationship between these conditions is summarized. The outcome of this research indicates that FXS is not a common cause of autism, although the number of individuals with FXS who meet diagnostic criteria for autism is higher than can be accounted for by chance. The major focus of this paper highlights that FXS is a well-defined neurogenetic disease that includes a cognitive behavioral phenotype, and has both a known biological cause and an increasing well-delineated pathogenesis. Autism is a behaviorally defined syndrome whose syndromic boundaries and biological causes are not known. These profound differences complicate comparisons and causal discussions. However, the behavioral neurogenetic information available about FXS suggests certain pathways for future research directed at elucidating the syndrome of autism. |
| | |
Authors:
|
C Feinstein; A L Reiss |
Related Documents
:
|
2300265 - Amyotrophic lateral sclerosis in a patient with fragile x syndrome. 6711595 - Fragile-x syndrome iii: dermatoglyphic studies in males. 17559295 - Narrative development in adolescents and young adults with fragile x syndrome. 3953655 - Autism in fragile x females. 2300265 - Amyotrophic lateral sclerosis in a patient with fragile x syndrome. 9801115 - Urologic screening for men with behçet's syndrome. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Journal of autism and developmental disorders Volume: 28 ISSN: 0162-3257 ISO Abbreviation: J Autism Dev Disord Publication Date: 1998 Oct |
Date Detail:
|
Created Date: 1999-01-05 Completed Date: 1999-01-05 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 7904301 Medline TA: J Autism Dev Disord Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 393-405 Citation Subset: IM |
Affiliation:
|
Division of Child and Adolescent Psychiatry and Child Development, Stanford University School of Medicine, California 94305-5719, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Autistic Disorder
/
etiology,
genetics* Female Fragile X Syndrome / complications, genetics* Humans Phenotype |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Autism: the phenotype in relatives.
Next Document: Chromosomal disorders and autism.