Document Detail

Autism, an extreme challenge to integrative medicine. Part 2: medical management.
MedLine Citation:
PMID:  12495373     Owner:  NLM     Status:  MEDLINE    
Autism and allied autistic spectrum disorders (ASD) present myriad behavioral, clinical, and biochemical abnormalities. Parental participation, advanced testing protocols, and eclectic treatment strategies have driven progress toward cure. Behavioral modification and structured education are beneficial but insufficient. Dietary restrictions, including removal of milk and other casein dairy products, wheat and other gluten sources, sugar, chocolate, preservatives, and food coloring are beneficial and prerequisite to benefit from other interventions. Individualized IgG or IgE testing can identify other troublesome foods but not non-immune mediated food sensitivities. Gastrointestinal improvement rests on controlling Candida and other parasites, and using probiotic bacteria and nutrients to correct dysbiosis and decrease gut permeability. Detoxification of mercury and other heavy metals by DMSA/DMPS chelation can have marked benefit. Documented sulfoxidation-sulfation inadequacies call for sulfur-sulfhydryl repletion and other liver p450 support. Many nutrient supplements are beneficial and well tolerated, including dimethylglycine (DMG) and a combination of pyridoxine (vitamin B6) and magnesium, both of which benefit roughly half of ASD cases. Vitamins A, B3, C, and folic acid; the minerals calcium and zinc; cod liver oil; and digestive enzymes, all offer benefit. Secretin, a triggering factor for digestion, is presently under investigation. Immune therapies (pentoxifyllin, intravenous immunoglobulin, transfer factor, and colostrum) benefit selected cases. Long-chain omega-3 fatty acids offer great promise. Current pharmaceuticals fail to benefit the primary symptoms and can have marked adverse effects. Individualized, in-depth clinical and laboratory assessments and integrative parent-physician-scientist cooperation are the keys to successful ASD management.
Parris M Kidd
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Alternative medicine review : a journal of clinical therapeutic     Volume:  7     ISSN:  1089-5159     ISO Abbreviation:  Altern Med Rev     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-23     Completed Date:  2003-03-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9705340     Medline TA:  Altern Med Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  472-99     Citation Subset:  K    
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MeSH Terms
Amino Acids / metabolism
Autistic Disorder / drug therapy,  etiology,  therapy*
Blood Coagulation Disorders / therapy
Chelating Agents / therapeutic use
Dietary Supplements
Disease Susceptibility / diagnosis
Food Habits
Food Hypersensitivity / complications
Gastrointestinal Agents / therapeutic use
Gastrointestinal Diseases / complications,  therapy
Mercury Poisoning / therapy
Peptides / metabolism
Secretin / therapeutic use
Reg. No./Substance:
0/Amino Acids; 0/Chelating Agents; 0/Gastrointestinal Agents; 0/Peptides; 1393-25-5/Secretin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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