Document Detail


Autism traits in individuals with agenesis of the corpus callosum.
MedLine Citation:
PMID:  23054201     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Autism spectrum disorders (ASD) have numerous etiologies, including structural brain malformations such as agenesis of the corpus callosum (AgCC). We sought to directly measure the occurrence of autism traits in a cohort of individuals with AgCC and to investigate the neural underpinnings of this association. We screened a large AgCC cohort (n = 106) with the Autism Spectrum Quotient (AQ) and found that 45 % of children, 35 % of adolescents, and 18 % of adults exceeded the predetermined autism-screening cut-off. Interestingly, performance on the AQ's imagination domain was inversely correlated with magnetoencephalography measures of resting-state functional connectivity in the right superior temporal gyrus. Individuals with AgCC should be screened for ASD and disorders of the corpus callosum should be considered in autism diagnostic evaluations as well.
Authors:
Yolanda C Lau; Leighton B N Hinkley; Polina Bukshpun; Zoe A Strominger; Mari L J Wakahiro; Simon Baron-Cohen; Carrie Allison; Bonnie Auyeung; Rita J Jeremy; Srikantan S Nagarajan; Elliott H Sherr; Elysa J Marco
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of autism and developmental disorders     Volume:  43     ISSN:  1573-3432     ISO Abbreviation:  J Autism Dev Disord     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-11     Completed Date:  2013-10-21     Revised Date:  2014-05-08    
Medline Journal Info:
Nlm Unique ID:  7904301     Medline TA:  J Autism Dev Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1106-18     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Agenesis of Corpus Callosum / physiopathology,  psychology*
Child
Child Development Disorders, Pervasive / diagnosis*,  physiopathology,  psychology
Child, Preschool
Female
Humans
Magnetic Resonance Imaging
Magnetoencephalography
Male
Questionnaires
Grant Support
ID/Acronym/Agency:
DC006435/DC/NIDCD NIH HHS; DC010145/DC/NIDCD NIH HHS; K02 NS052192/NS/NINDS NIH HHS; K02 NS052192/NS/NINDS NIH HHS; K23 MH083890/MH/NIMH NIH HHS; K23 MH083890/MH/NIMH NIH HHS; KL2 RR024130/RR/NCRR NIH HHS; KL2 RR024130/RR/NCRR NIH HHS; NS067962/NS/NINDS NIH HHS; NS64060/NS/NINDS NIH HHS; R01 DC004855/DC/NIDCD NIH HHS; UL1 RR024131/RR/NCRR NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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