Document Detail

Autism After Infection, Febrile Episodes, and Antibiotic Use During Pregnancy: An Exploratory Study.
MedLine Citation:
PMID:  23147969     Owner:  NLM     Status:  Publisher    
OBJECTIVES:Results of animal studies suggest that maternal immune activation during pregnancy causes deficiencies in fetal neurodevelopment. Infectious disease is the most common path to maternal immune activation during pregnancy. The goal of this study was to determine the occurrence of common infections, febrile episodes, and use of antibiotics reported by the mother during pregnancy and the risk for autism spectrum disorder (ASD) and infantile autism in the offspring.METHODS:We used a population-based cohort consisting of 96 736 children aged 8 to 14 years and born from 1997 to 2003 in Denmark. Information on infection, febrile episodes, and use of antibiotics was self-reported through telephone interviews during pregnancy and early postpartum. Diagnoses of ASD and infantile autism were retrieved from the Danish Psychiatric Central Register; 976 children (1%) from the cohort were diagnosed with ASD.RESULTS:Overall, we found little evidence that various types of mild common infectious diseases or febrile episodes during pregnancy were associated with ASD/infantile autism. However, our data suggest that maternal influenza infection was associated with a twofold increased risk of infantile autism, prolonged episodes of fever caused a threefold increased risk of infantile autism, and use of various antibiotics during pregnancy were potential risk factors for ASD/infantile autism.CONCLUSIONS:Our results do not suggest that mild infections, febrile episodes, or use of antibiotics during pregnancy are strong risk factors for ASD/infantile autism. The results may be due to multiple testing; the few positive findings are potential chance findings.
Hjördis Ósk Atladóttir; Tine Brink Henriksen; Diana E Schendel; Erik T Parner
Related Documents :
1258639 - Massive chronic feto-maternal bleeding associated with placental chorioangiomas.
24891469 - Placental malaria is rare among zanzibari pregnant women who did not receive intermitte...
16728419 - Increased risk of placenta previa in pregnancies following ivf/icsi; a comparison of ar...
11023169 - Maternal complications with placenta previa.
23876079 - Local illness concepts and their relevance for the prevention and control of malaria du...
24591439 - Treatment of suspected hyper-reactive malarial splenomegaly (hms) in pregnancy with mef...
15044599 - Oxytocin receptor gene expression of estrogen-stimulated human myometrium in extracorpo...
3381869 - Intrauterine adhesions: hysteroscopic diagnosis, classification, treatment, and reprodu...
7546529 - Thrombotic thrombocytopenic purpura in pregnancy: successful treatment with plasma exch...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-12
Journal Detail:
Title:  Pediatrics     Volume:  -     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Departments of Public Health, Section of Epidemiology and.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Prevalence of Overweight in Dutch Children With Down Syndrome.
Next Document:  Informed Choice for Newborn Blood Spot Screening in the United Kingdom: A Survey of Parental Percept...