| Autacoids affecting vascular tone in the human fetal extracorporeal circulation. | |
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MedLine Citation:
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PMID: 1352488 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The human fetal extracorporeal circulation is normally a vasodilated, low pressure system. 2. As this vasculature lacks innervation, autacoids have been postulated as being of great importance in controlling its tone. 3. This has now been confirmed by pharmacological in vitro techniques, particularly utilizing perfusion of the isolated umbilical cord and placental lobule. 4. The fetal umbilical-placental vessels are sensitive to a wide range of vasoconstrictor autacoids, some of which can cause intense vasospasm. 5. Thromboxane A2 receptors have been identified in both umbilical vein and placental villous vessels. 6. Prostacyclin and endothelial cell-derived relaxing factor (or nitric oxide) may be largely responsible for the low vascular resistance normally found in the fetal extracorporeal circulation. 7. Immediately after birth it is likely that stimuli such as cooling, stretching and handling of the umbilical cord cause release of eicosanoids and other autacoids from the vessels, leading to their complete closure. |
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Authors:
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W A Walters |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical and experimental pharmacology & physiology Volume: 19 ISSN: 0305-1870 ISO Abbreviation: Clin. Exp. Pharmacol. Physiol. Publication Date: 1992 Jan |
Date Detail:
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Created Date: 1992-08-07 Completed Date: 1992-08-07 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 3-8 Citation Subset: IM |
Affiliation:
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Discipline of Reproductive Medicine, Faculty of Medicine, University of Newcastle, NSW Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Autacoids
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pharmacology,
physiology* Epoprostenol / pharmacology Female Humans Nitric Oxide / pharmacology Placenta / blood supply*, drug effects Pregnancy Umbilical Cord / blood supply*, drug effects, physiology Vasoconstriction* / drug effects Vasodilation* / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Autacoids; 10102-43-9/Nitric Oxide; 35121-78-9/Epoprostenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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