Document Detail


The Australian polidocanol (aethoxysklerol) study. Results at 2 years.
MedLine Citation:
PMID:  7728486     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: An ongoing study of the safety and effectiveness of polidocanol by 98 investigators in Australia infecting 16,804 limbs over 2 years. OBJECTIVE: To evaluate the complications of polidocanol and compare its effectiveness and complications with sodium tetradecyl sulphate (STD) and hypertonic saline. METHODS: A single-arm prospective study of polidocanol complications and its effectiveness as a sclerosant was performed. This was compared with each investigator's previous experience with other sclerosing agents. Patients had either varicose veins or venule ectasias and/or spider veins (telangiectasia). A total of 16,804 limbs were injected by 98 investigators. Sclerotherapy was performed with 0.5% or 1% polidocanol for telangiectasias or spider veins, and with 3% polidocanol for varicose veins. The effectiveness of the sclerotherapy and any complications were reported during a 2-year period. RESULTS: There were very few complications reported with polidocanol. There were no reported deaths or anaphylaxis. The investigators with previous experience of other sclerosants considered that the effectiveness of polidocanol was superior to STD (85%) and hypertonic saline (84%). Ninety percent of investigators considered that polidocanol had less frequent complications than STD, and 80% considered that these were less severe. Seventy-four percent considered that polidocanol had fewer side effects than hypertonic saline, and 74% considered that these were less severe. CONCLUSIONS: Polidocanol is an effective sclerosant that has few complications.
Authors:
P Conrad; G M Malouf; M C Stacey
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]     Volume:  21     ISSN:  1076-0512     ISO Abbreviation:  Dermatol Surg     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-05-26     Completed Date:  1995-05-26     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  9504371     Medline TA:  Dermatol Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  334-6; discussion 337-8     Citation Subset:  IM    
Affiliation:
Department of Surgery, Nepean Hospital, Sydney, Australia.
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MeSH Terms
Descriptor/Qualifier:
Anesthetics, Local / adverse effects,  therapeutic use*
Double-Blind Method
Humans
Hypertonic Solutions / adverse effects,  therapeutic use
Polyethylene Glycols / adverse effects,  therapeutic use*
Sclerosing Solutions / adverse effects,  therapeutic use*
Sodium Tetradecyl Sulfate / adverse effects,  therapeutic use
Telangiectasis / therapy
Varicose Veins / therapy
Chemical
Reg. No./Substance:
0/Anesthetics, Local; 0/Hypertonic Solutions; 0/Polyethylene Glycols; 0/Sclerosing Solutions; 1191-50-0/Sodium Tetradecyl Sulfate; 9002-92-0/polidocanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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