| Australian Guidelines for the assessment of iron overload and iron chelation in transfusion-dependent thalassaemia major, sickle cell disease and other congenital anaemias. | |
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MedLine Citation:
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PMID: 21615659 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Iron overload is the most important cause of mortality in patients with thalassaemia major. Iron chelation is therefore a critical issue in the management of these patients and others with transfusion-dependent haemoglobinopathies and congenital anaemias. In recent years, significant developments have been made in the assessment of iron overload, including the use of MRI for measuring liver and cardiac iron. Advances in the modalities available for iron chelation, with the advent of oral iron chelators including deferiprone and deferasirox in addition to parenteral desferrioxamine, have expanded treatment options. A group of Australian haematologists have convened to formulate guidelines for managing iron overload on the basis of available evidence, and to describe best consensus practice as undertaken in major Australian Haemoglobinopathy units. The results of their discussions are described in this article, with the aim of providing guidance in the management of iron overload in these patients. |
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Authors:
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Pj Ho; L Tay; R Lindeman; L Catley; Dk Bowden |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-25 |
Journal Detail:
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Title: Internal medicine journal Volume: - ISSN: 1445-5994 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101092952 Medline TA: Intern Med J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Sydney South West Area Health Service. Journal compilation © 2011 Royal Australasian College of Physicians. |
Affiliation:
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Senior Staff Haematologist and Clinical Associate Professor, Institute of Haematology, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050; Bosch Institute, University of Sydney. Tel (02) 95158457 Fax (02) 95156698 Dept. of Haematology, Royal Adelaide Hospital, North Terrace, Adelaide, SA 5000 Department of Haematology, Prince of Wales Hospital, Barker Street, Randwick NSW 2031 Dept. of Haematology, Mater Hospital, Raymond Terrace, South Brisbane, QLD 4101 Thalassaemia Services Victoria, Monash Medical Centre, 246 Clayton Rd, Clayton, VIC 3168. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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