Document Detail


Auscultation and echocardiographic findings in Bull Terriers with and without polycystic kidney disease.
MedLine Citation:
PMID:  15957386     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate a possible association between Bull Terrier polycystic kidney disease (BTPKD) and cardiac disease, to determine the prevalence of mitral valve disease (MVD) and left ventricular outflow tract obstruction (LVOTO) in the Australian Bull Terrier population, and to compare auscultation and echocardiography in detection of cardiac disease in Bull Terriers. DESIGN: Ninety-nine Bull Terriers, ranging in age from 8 weeks to 13 years and 11 months were auscultated and examined using renal ultrasonography; 86 were also examined using echocardiography. The prevalence and severity of heart defects in dogs with BTPKD was compared with that in dogs without BTPKD. RESULTS: Nineteen of these 99 dogs were diagnosed with BTPKD. Forty-two percent of Bull Terriers with BTPKD and 28% of those without BTPKD had murmurs characteristic of mitral regurgitation or LVOTO. How recently an animal was descended from an ancestor with BTPKD was associated with presence (P = 0.008) and loudness of a murmur (P = 0.009). Overall, echocardiography detected MVD in 39% of Bull Terriers, with increased prevalence in older animals (P = 0.003). Mitral stenosis was found in eight cases. Fifty-three percent of dogs in this study had evidence of LVOTO, with obstruction consisting of a complex of lesions including dynamic or fixed subvalvular LVOTO, significantly narrowed left ventricular outflow tract or valvular aortic stenosis. Dogs with BTPKD, or those descended from dogs with BTPKD, were more likely to have MVD (P = 0.006), and while LVOTO was not more common in these dogs, if they did have LVOTO, they were more likely to have severe obstruction than dogs with no ancestors with BTPKD (analysed in three ways P = 0.028 to 0.001). In this study, 46% of Bull Terriers without a murmur or arrhythmia had cardiac disease detected on echocardiographic examination. CONCLUSION: Cardiac disease, especially MVD and LVOTO, was common in Bull Terriers in this study, and those with BTPKD had an increased risk of cardiac abnormalities. Auscultation did not detect a significant number of Bull Terriers with cardiac disease.
Authors:
C A O'Leary; B M Mackay; R H Taplin; R B Atwell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Australian veterinary journal     Volume:  83     ISSN:  0005-0423     ISO Abbreviation:  Aust. Vet. J.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-06-16     Completed Date:  2005-08-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370616     Medline TA:  Aust Vet J     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  270-5     Citation Subset:  IM    
Affiliation:
School of Veterinary Science, The University of Queensland, St Lucia, Queensland 4072.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Breeding
Dog Diseases / diagnosis,  genetics,  ultrasonography*
Dogs
Echocardiography / methods,  veterinary*
Female
Genetic Predisposition to Disease
Heart Ventricles / ultrasonography
Male
Mitral Valve Insufficiency / complications,  genetics,  ultrasonography,  veterinary*
Polycystic Kidney, Autosomal Dominant / complications,  genetics,  ultrasonography,  veterinary*
Ventricular Outflow Obstruction / complications,  genetics,  ultrasonography,  veterinary*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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