Document Detail

Aureobasidin, new antifouling metabolite from marine-derived fungus Aureobasidium sp.
MedLine Citation:
PMID:  19413119     Owner:  NLM     Status:  MEDLINE    
Two antifouling compounds, aureobasidin (1), a new ester with an unusual 4,6-dihydroxydecanoic acid residue, and (3R,5S)-3,5-dihydroxydecanoic acid (2), were isolated from the marine-derived fungus Aureobasidium sp., in addition to (5R,3Z)-5-hydroxydec-3-enoic acid (3) and (R)-3-hydroxydecanoic acid (4). The structures were unambiguously established by IR, 1D and 2D NMR spectroscopic and mass spectral data. Compounds 1-3 were found to be active against Bacillus subtilis, Escherichia coli and Staphyllococcus aureus. Compound 3 showed fungistatic activity against Candida albicans.
Ahmed Abdel-Lateff; Ehab S Elkhayat; Mostafa A Fouad; Tatsufumi Okino
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Natural product communications     Volume:  4     ISSN:  1934-578X     ISO Abbreviation:  Nat Prod Commun     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-05-05     Completed Date:  2009-06-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101477873     Medline TA:  Nat Prod Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  389-94     Citation Subset:  IM    
Department ofPharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
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MeSH Terms
Ascomycota / chemistry*
Bacillus subtilis / drug effects
Candida albicans / drug effects
Decanoic Acids / analysis*,  isolation & purification*,  pharmacology
Escherichia coli / drug effects
Esters / analysis*,  isolation & purification*,  pharmacology
Magnetic Resonance Spectroscopy
Molecular Structure
Staphylococcus aureus / drug effects
Reg. No./Substance:
0/Decanoic Acids; 0/Esters

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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