Document Detail


Aurantoside K, a new antifungal tetramic acid glycoside from a Fijian marine sponge of the genus Melophlus.
MedLine Citation:
PMID:  22363230     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new tetramic acid glycoside, aurantoside K, was isolated from a marine sponge belonging to the genus Melophlus. The structure of the compound was elucidated on the basis of spectroscopic analysis (¹H NMR, ¹H-¹H COSY, HSQC, and HMBC, as well as high-resolution ESILCMS). Aurantoside K did not show any significant activity in antimalarial, antibacterial, or HCT-116 cytotoxicity assays, but exhibited a wide spectrum of antifungal activity against wild type Candida albicans, amphotericin-resistant C. albicans, Cryptococcus neoformans, Aspergillus niger, Penicillium sp., Rhizopus sporangia and Sordaria sp.
Authors:
Rohitesh Kumar; Ramesh Subramani; Klaus-D Feussner; William Aalbersberg
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-01-18
Journal Detail:
Title:  Marine drugs     Volume:  10     ISSN:  1660-3397     ISO Abbreviation:  Mar Drugs     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-02-24     Completed Date:  2012-06-29     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101213729     Medline TA:  Mar Drugs     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  200-8     Citation Subset:  IM    
Affiliation:
Centre for Drug Discovery and Conservation, Institute of Applied Sciences, The University of the South Pacific, Suva, Fiji Islands.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antifungal Agents / chemistry,  isolation & purification*,  pharmacology
Glycosides / chemistry,  isolation & purification*,  pharmacology
Magnetic Resonance Spectroscopy
Porifera / chemistry*
Pyrrolidinones / chemistry,  isolation & purification*,  pharmacology
Grant Support
ID/Acronym/Agency:
U01-TW007401/TW/FIC NIH HHS
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Glycosides; 0/Pyrrolidinones; 0/aurantoside K; 503-83-3/tetramic acid
Comments/Corrections

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