| Augmented responses to vasoconstrictor stimuli in hypercholesterolemic and atherosclerotic monkeys. | |
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MedLine Citation:
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PMID: 6733866 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined effects of hypercholesterolemia and atherosclerosis on vasoconstrictor responses to norepinephrine and serotonin. Responses were compared in normal, atherosclerotic, and hypercholesterolemic but non-atherosclerotic cynomolgus monkeys. The hindlimb was perfused at constant flow so that changes in perfusion pressure indicated changes in vascular resistance. We measured the pressure gradient from the iliac to the dorsal pedal artery so that responses of the large artery segment could be determined. Serotonin decreased total hindlimb resistance in normal and hypercholesterolemic monkeys, but increased total resistance in atherosclerotic monkeys. There was a greater than 10-fold increase in constrictor responses of large arteries to serotonin in atherosclerotic monkeys, compared with normal and hypercholesterolemic monkeys. In contrast, we found that vasoconstrictor responses to norepinephrine are normal in atherosclerotic monkeys and increased in hypercholesterolemic monkeys prior to development of atherosclerosis. Hypercholesterolemia augmented responses of small vessels to norepinephrine. We conclude that, during early stages of hypercholesterolemia in cynomolgus monkeys, vasoconstrictor responses to norepinephrine are increased in small vessels. At a later stage, as atherosclerosis develops, responses to norepinephrine return to normal, but vasoconstrictor effects of large arteries to serotonin are greatly potentiated. |
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Authors:
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D D Heistad; M L Armstrong; M L Marcus; D J Piegors; A L Mark |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Circulation research Volume: 54 ISSN: 0009-7330 ISO Abbreviation: Circ. Res. Publication Date: 1984 Jun |
Date Detail:
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Created Date: 1984-08-07 Completed Date: 1984-08-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0047103 Medline TA: Circ Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 711-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteriosclerosis / metabolism, physiopathology* Blood Pressure / drug effects Cholesterol / blood Hindlimb Hypercholesterolemia / metabolism, physiopathology* Macaca fascicularis Norepinephrine / pharmacology* Serotonin / pharmacology* Triglycerides / blood Vascular Resistance / drug effects Vasoconstriction / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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HL 14230/HL/NHLBI NIH HHS; HL 14388/HL/NHLBI NIH HHS; HL 16066/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Triglycerides; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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