| Augmented response in plasma atrial natriuretic peptide to dynamic exercise in patients with congestive heart failure. | |
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MedLine Citation:
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PMID: 8996680 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neurohormonal activation is present and neurohormonal responses to dynamic exercise are altered in patients with congestive heart failure (CHF). The aim of this study was to determine if the responses of atrial natriuretic peptide (ANP) normalized for peak oxygen consumption (peak VO2) to exercise are augmented in patients with CHF. Ventilatory and ANP responses were assessed in 28 patients with CHF (NYHA classes II: 16, III: 12), 17 patients in NYHA class I, and 14 normal subjects during symptom-limited cardiopulmonary exercise testing. Plasma ANP was measured at rest and immediately after peak exercise. The increase in ANP was divided by peak VO2 and this ratio [ANP-Exercise Ratio: (peak ANP-rest ANP)/peak VO2] was compared among the 3 groups. Peak VO2 (Normal, NYHA I, CHF: 29.9 +/- 1.7, 24.0 +/- 1.3, 17.4 +/- 0.8 ml/min per kg), anaerobic threshold and peak work rate were lower in patients with CHF. The resting ANP level was significantly higher in patients with CHF (Normal, NYHA I, CHF: 35.4 +/- 4.6, 42.9 +/- 5.8, 80.8 +/- 12.9 pg/ml). The ANP level increased during exercise in all 3 groups, and patients with CHF had a significantly higher ANP level than normal subjects and NYHA class I patients (Normal, NYHA I, CHF: 65.3 +/- 10.7, 75.9 +/- 14.4, 141.6 +/- 20.1 pg/ml). The ANP-Exercise Ratio in patients with CHF was significantly higher than those in normal subjects and NYHA class I patients (Normal, NYHA I, CHF: 0.96 +/- 0.26, 1.32 +/- 0.38, 3.59 +/- 0.72). These data suggest that patients with CHF but not those in NYHA class I have an augmented ANP response, as reflected by both absolute ANP levels and by the exercise ratio, which was normalized by the peak exercise level. |
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Authors:
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M Kato; T Kinugawa; H Omodani; S Osaki; K Ogino; I Hisatome; H Miyakoda; Y Fujimoto |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Japanese circulation journal Volume: 60 ISSN: 0047-1828 ISO Abbreviation: Jpn. Circ. J. Publication Date: 1996 Dec |
Date Detail:
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Created Date: 1997-03-31 Completed Date: 1997-03-31 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7806868 Medline TA: Jpn Circ J Country: JAPAN |
Other Details:
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Languages: eng Pagination: 909-16 Citation Subset: IM; S |
Affiliation:
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1st Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Atrial Natriuretic Factor
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blood* Blood Pressure / physiology Cerebral Ventricles / metabolism Female Heart Diseases / etiology, physiopathology Heart Failure / blood*, physiopathology* Heart Rate / physiology Humans Male Middle Aged Natriuretic Peptide, Brain Nerve Tissue Proteins / blood, secretion Oxygen Consumption / physiology Physical Exertion / physiology* Respiration / physiology |
| Chemical | |
Reg. No./Substance:
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0/Nerve Tissue Proteins; 114471-18-0/Natriuretic Peptide, Brain; 85637-73-6/Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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