Document Detail

Augmented production of soluble CD93 in patients with systemic sclerosis and clinical association with severity of skin sclerosis.
MedLine Citation:
PMID:  22540233     Owner:  NLM     Status:  Publisher    
Background:  The cell surface protein CD93, expressed on endothelial and myeloid cells, mediates phagocytosis, inflammation and cell adhesion. A soluble form of CD93 (sCD93) is released during inflammation. Objectives:  To determine the serum sCD93 level and its association with clinical parameters in patients with systemic sclerosis (SSc). Methods:  Serum sCD93 level was examined by enzyme-linked immunosorbent assay in 59 patients with SSc, 24 patients with systemic lupus erythematosus and 47 healthy individuals. The expression of CD93 in skin tissues was examined immunohistochemically. In a retrospective longitudinal study, sera from 11 patients with SSc were analysed. Results:  Serum sCD93 level was increased in patients with SSc compared with healthy individuals (P<0.001). Patients with diffuse cutaneous SSc showed greater levels of sCD93 than those with limited cutaneous SSc (P<0.01) or systemic lupus erythematosus (P<0.01). Serum sCD93 level correlated positively with the severity of skin sclerosis. Strong CD93 immunostaining was observed on endothelial cells in lesional skin tissues. In the longitudinal study, sCD93 level decreased in parallel with improvement in skin sclerosis. Conclusions:  Serum sCD93 level is increased in patients with SSc and correlates with the severity and activity of skin sclerosis. CD93 may contribute to the development of skin fibrosis in SSc.
K Yanaba; Y Asano; S Noda; K Akamata; N Aozasa; T Taniguchi; T Takahashi; Y Ichimura; T Toyama; H Sumida; Y Kuwano; Y Tada; M Sugaya; T Kadono; S Sato
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-27
Journal Detail:
Title:  The British journal of dermatology     Volume:  -     ISSN:  1365-2133     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 British Association of Dermatologists.
Department of Dermatology, Faculty of Medicine, The University of Tokyo, Japan.
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