Document Detail

Augmented plasma protein C activity after coronary thrombolysis with urokinase in patients with acute myocardial infarction.
MedLine Citation:
PMID:  1387346     Owner:  NLM     Status:  MEDLINE    
Coronary thrombolysis reduces morbidity and mortality in patients with acute myocardial infarction, however, the exact effects of thrombolytic agents on the status of intrinsic hemostases are not fully understood. In the present study, we examined serial changes in plasma thrombin and protein C activities of 6 patients with acute myocardial infarction treated with urokinase. Fibrinolysis occurred immediately after urokinase injection with an increase in the plasma thrombin-antithrombin III complex, suggesting a subsequent procoagulant state due to thrombin generation. Correspondent increases in plasma protein C activity were observed, however, protein S levels did not change at all. Our findings suggest that urokinase administration for coronary thrombolysis not only causes fibrinolysis, but also induces thrombin activity, which may be antagonized by augmented intrinsic protein C activity.
S Goto; S Handa; Y Kawai; K Watanabe; S Abe; E Takahashi; S Hori; Y Ikeda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiology     Volume:  80     ISSN:  0008-6312     ISO Abbreviation:  Cardiology     Publication Date:  1992  
Date Detail:
Created Date:  1992-10-01     Completed Date:  1992-10-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  252-6     Citation Subset:  IM    
Cardiopulmonary Division, Keio University School of Medicine, Tokyo, Japan.
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MeSH Terms
Antithrombin III / metabolism
Blood Proteins / metabolism
Glycoproteins / metabolism
Middle Aged
Myocardial Infarction / blood,  drug therapy*
Peptide Hydrolases / metabolism
Protein C / metabolism*
Protein S
Thrombin / metabolism
Thrombolytic Therapy*
Urokinase-Type Plasminogen Activator / therapeutic use*
Reg. No./Substance:
0/Blood Proteins; 0/Glycoproteins; 0/Protein C; 0/Protein S; 0/antithrombin III-protease complex; 9000-94-6/Antithrombin III; EC 3.4.-/Peptide Hydrolases; EC; EC Plasminogen Activator

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