| Augmented plasma protein C activity after coronary thrombolysis with urokinase in patients with acute myocardial infarction. | |
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MedLine Citation:
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PMID: 1387346 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Coronary thrombolysis reduces morbidity and mortality in patients with acute myocardial infarction, however, the exact effects of thrombolytic agents on the status of intrinsic hemostases are not fully understood. In the present study, we examined serial changes in plasma thrombin and protein C activities of 6 patients with acute myocardial infarction treated with urokinase. Fibrinolysis occurred immediately after urokinase injection with an increase in the plasma thrombin-antithrombin III complex, suggesting a subsequent procoagulant state due to thrombin generation. Correspondent increases in plasma protein C activity were observed, however, protein S levels did not change at all. Our findings suggest that urokinase administration for coronary thrombolysis not only causes fibrinolysis, but also induces thrombin activity, which may be antagonized by augmented intrinsic protein C activity. |
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Authors:
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S Goto; S Handa; Y Kawai; K Watanabe; S Abe; E Takahashi; S Hori; Y Ikeda |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cardiology Volume: 80 ISSN: 0008-6312 ISO Abbreviation: Cardiology Publication Date: 1992 |
Date Detail:
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Created Date: 1992-10-01 Completed Date: 1992-10-01 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 1266406 Medline TA: Cardiology Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 252-6 Citation Subset: IM |
Affiliation:
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Cardiopulmonary Division, Keio University School of Medicine, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antithrombin III / metabolism Blood Proteins / metabolism Glycoproteins / metabolism Humans Male Middle Aged Myocardial Infarction / blood, drug therapy* Peptide Hydrolases / metabolism Protein C / metabolism* Protein S Thrombin / metabolism Thrombolytic Therapy* Urokinase-Type Plasminogen Activator / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 0/Glycoproteins; 0/Protein C; 0/Protein S; 0/antithrombin III-protease complex; 9000-94-6/Antithrombin III; EC 3.4.-/Peptide Hydrolases; EC 3.4.21.5/Thrombin; EC 3.4.21.73/Urokinase-Type Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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