Document Detail

Augmented peripheral chemoreflex in patients with heart failure and inspiratory muscle weakness.
MedLine Citation:
PMID:  20096381     Owner:  NLM     Status:  MEDLINE    
We hypothesized that heart failure patients with inspiratory muscle weakness (IMW) present greater peripheral chemoreflex responsiveness and augmented exercise ventilatory oscillation compared to patients with preserved inspiratory muscle strength. We studied 19 heart failure patients: 9 with IMW (maximal inspiratory pressure [PImax]<70% of predicted) and 10 with preserved inspiratory muscle strength. Inspiratory muscle strength was measured via pressure transducer. Peripheral chemoreflex was evaluated by the single-breath CO(2) test. Exercise ventilatory oscillation was determined as the ratio between amplitude and mean of each oscillation during incremental exercise. Patients with IMW had greater peripheral chemoreflex response (0.11+/-0.03 l min(-1) Torr(-1)) than those with preserved inspiratory muscle strength (0.07+/-0.03 l min(-1) Torr(-1), p=0.02). Moreover, there was a significant and inverse correlation between PImax and peripheral chemoreflex response (r=-0.57, p=0.01). Likewise, there was a significant and inverse correlation between PImax and ventilatory oscillations (r=-0.46, p=0.04). Our findings indicate that IMW is linked to increased peripheral chemoreflex and augmented exercise ventilatory oscillation in patients with chronic heart failure.
Carine C Callegaro; Denis Martinez; Paula A B Ribeiro; Marta Brod; Jorge P Ribeiro
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-21
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  171     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-29     Completed Date:  2010-06-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  31-5     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Exercise Pathophysiology Research Laboratory, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil.
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MeSH Terms
Carbon Dioxide
Chemoreceptor Cells / physiology*
Exercise Test
Intermittent Positive-Pressure Ventilation / methods
Middle Aged
Muscle Strength / physiology
Muscle Weakness / pathology*
Muscle, Skeletal / physiopathology*
Predictive Value of Tests
Pulmonary Ventilation / physiology
Ventricular Dysfunction, Left / pathology*
Reg. No./Substance:
124-38-9/Carbon Dioxide

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