Document Detail


Augmented expression of atrial myosin light chain 1 in ventricular aneurysms of human: enzyme immunoassay for atrial myosin light chain 1.
MedLine Citation:
PMID:  7857308     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We established an enzyme immunoassay (EIA) for atrial myosin light chain 1 (ALC1) using monoclonal antibodies KA1 and KB1, which were specific for ALC1 and for both ALC1 and ventricular myosin light chain 1, respectively. The serum ALC1 levels of healthy subjects were 0.28 +/- 0.14 ng/ml (mean +/- SD). The tissue ALC1 levels of normal adult human atria were much higher than those of ventricles (p < 0.01, 2,120 +/- 1,200 in right atria, 2,180 +/- 1,450 in left atria vs. 36.0 +/- 20.2 in right ventricles, 37.7 +/- 15.3 in left ventricles, ng/mg of proteins). The tissue ALC1 levels of ventricular aneurysms were significantly higher than those of normal ventricles (p < 0.01, 206.7 +/- 101.8). These results indicate that ALC1 is augmented in aneurysms and that the EIA provides a useful tool to investigate the roles of ALC1.
Authors:
K Fujimoto; H Yasue; S Hashida; K Nakao; E Ishikawa; E Miyamoto
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  207     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-03-14     Completed Date:  1995-03-14     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  75-9     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Kumamoto University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Analysis of Variance
Antibodies, Monoclonal
Female
Gene Expression*
Heart Aneurysm / metabolism*
Heart Atria
Heart Ventricles
Humans
Immunoenzyme Techniques
Male
Myocardial Infarction / metabolism
Myocardium / metabolism*
Myosins / analysis,  biosynthesis*,  blood
Reference Values
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; EC 3.6.4.1/Myosins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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